{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:54:23Z","timestamp":1760316863971,"version":"build-2065373602"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T00:00:00Z","timestamp":1309824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The concept of in situ neoplasia, already well acknowledged in epithelial tumors, has now been extended to lymphoid neoplasms. Among germinal center (GC)\u2010derived lymphomas, a type of \u201cin situ follicular lymphoma (FL)\u201d has been described in which cells that strongly express BCL2 are observed in histologically abnormal follicles. In this commentary, the author suggests that another GC\u2010derived lymphoma, ie, nodular lymphocyte\u2010predominant Hodgkin lymphoma with a micronodular pattern in which small GCs or broken\u2010up GCs are present within nodules, may be regarded as an early lesion limited to GC. Like \u201cin situ FL,\u201d this is likely to be an in situ step that potentially leads to overt lymphoma. Cancer 2012;. \u00a9 2011 American Cancer Society.<\/jats:p>","DOI":"10.1002\/cncr.26228","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T12:20:35Z","timestamp":1309868435000},"page":"15-16","source":"Crossref","is-referenced-by-count":3,"title":["Does \u201cin situ lymphoma\u201d occur as a distinct step in the development of nodular lymphocyte\u2010predominant Hodgkin lymphoma?"],"prefix":"10.1002","volume":"118","author":[{"given":"Antonino","family":"Carbone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,5]]},"reference":[{"key":"e_1_2_3_2_2","first-page":"220","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Harris NL","year":"2008"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07651.x"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-299628"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200310000-00007"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1003733"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.26228","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.26228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:13:02Z","timestamp":1760296382000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.26228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,5]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1002\/cncr.26228"],"URL":"https:\/\/doi.org\/10.1002\/cncr.26228","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2011,7,5]]}}}