{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:08:23Z","timestamp":1792008503738,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>For <jats:italic>BRCA1\/BRCA2<\/jats:italic> gene testing to benefit public health, mutation carriers must initiate appropriate risk management strategies. There has been little research examining the long\u2010term use and prospective predictors of the full range of risk management behaviors among women who have undergone <jats:italic>BRCA1\/2<\/jats:italic> testing. We evaluated long\u2010term uptake and predictors of risk\u2010reducing mastectomy (RRM), risk\u2010reducing bilateral salpingo\u2010oophorectomy (RRBSO), chemoprevention, and cancer screening among women at a mean of 5.3 years after testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The study participants comprised 465 women who underwent <jats:italic>BRCA1\/2<\/jats:italic> testing. Prior to genetic counseling, we measured family\/personal cancer history, sociodemographics, perceived risk, cancer\u2010specific distress, and general distress. We contacted patients at a mean of 5.3 years after testing to measure use of RRM, RRBSO, chemoprevention, and breast and ovarian cancer screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Among participants with intact breasts and\/or ovaries at the time of testing, <jats:italic>BRCA1\/2<\/jats:italic> carriers were significantly more likely to obtain RRM (37%) and RRBSO (65%) compared with women who received uninformative (RRM, 6.8%; RRBSO, 13.3%) or negative (RRM, 0%; RRBSO, 1.9%) results. Among carriers, precounseling anxiety was associated with subsequent uptake of RRM. RRO was predicted by age. Carriers were also more likely have used breast cancer chemoprevention and have undergone magnetic resonance imaging screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION:<\/jats:title><jats:p>This prospective evaluation of the uptake and predictors of long\u2010term management outcomes provides a clearer picture of decision making in this population. At a mean of 5.3 years after testing, more than 80% of carriers had obtained RRM, RRBSO, or both, suggesting that <jats:italic>BRCA1\/2<\/jats:italic> testing is likely to have a favorable effect on breast and ovarian cancer outcomes. Cancer 2011;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26294","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T11:18:15Z","timestamp":1309432695000},"page":"510-517","source":"Crossref","is-referenced-by-count":110,"title":["Long\u2010term outcomes of <i>BRCA1\/BRCA2<\/i> testing: risk reduction and surveillance"],"prefix":"10.1002","volume":"118","author":[{"given":"Marc D.","family":"Schwartz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi D.","family":"Graves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Poggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth N.","family":"Peshkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy","family":"Gell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton","family":"Finch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Perley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.10.080"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.19.3938"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00505-5"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602703"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020119"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012158"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1237"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.18.2251"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10102"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2000.0684"},{"key":"e_1_2_7_12_2","first-page":"1115","article-title":"Utilization of breast cancer screening in a clinically based sample of women after BRCA1\/2 testing","volume":"11","author":"Peshkin BN","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.5.1260"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9423-5"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.086"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2008.0067"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2007.n.053"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23340"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.6078"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0171"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603610"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00665.x"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01329.x"},{"key":"e_1_2_7_24_2","unstructured":"National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines in Oncology. 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