{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:54:48Z","timestamp":1762458888883,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T00:00:00Z","timestamp":1310428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The nucleotide excision repair (NER) pathway is the principal DNA repair pathway for removing bulky platinum DNA adducts. Suboptimal DNA repair may lead to improved response to platinum agents. The objective of this study was to determine whether single\u2010nucleotide polymorphisms (SNPs) in NER pathway genes could be markers of platinum response in ovarian cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The authors identified patients with advanced\u2010stage, papillary serous ovarian cancer who underwent primary cytoreductive surgery followed by platinum\u2010based chemotherapy. DNA was isolated from peripheral blood specimens. Twenty\u2010two SNPs within NER genes (xeroderma pigmentosum [XP] complementation group A [<jats:italic>XPA<\/jats:italic>], XPB\/excision repair cross\u2010complementing rodent repair deficiency, complementation group 3 [<jats:italic>ERCC3<\/jats:italic>], <jats:italic>XPC<\/jats:italic>, XPD\/<jats:italic>ERCC2<\/jats:italic>, XPF\/<jats:italic>ERCC4<\/jats:italic>, XPG\/<jats:italic>ERCC5<\/jats:italic>, Cockayne syndrome group B protein [CSB]\/<jats:italic>ERCC8<\/jats:italic>, <jats:italic>ERCC1<\/jats:italic>) were genotyped using polymerase chain reaction analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>In total, 139 patients with stage III and IV papillary serous ovarian cancer were genotyped. The <jats:italic>XPC<\/jats:italic> (reference SNP 3731108 [rs3731108]) adenosine\u2010guanine (AG)\/AA genotype versus the GG genotype was associated with prolonged a progression\u2010free survival (PFS) of 21.3 months versus 13.4 months (hazard ratio [HR], 0.63; 95% confidence interval [CI], 0.42\u20100.95; <jats:italic>P<\/jats:italic> = .03). The <jats:italic>XPC<\/jats:italic> (rs1124303) guanosine\u2010thymidine (GT)\/GG genotype versus the TT genotype was associated with a prolonged PFS of 22.8 months versus 14.9 months (HR, 0.47; 95% CI, 0.24\u20100.94; <jats:italic>P<\/jats:italic> = .03). The <jats:italic>XPC<\/jats:italic> poly(AT) (PAT) (\u2212\/+)\/(\u2212\/\u2212) genotype versus the (+\/+) genotype was associated with a prolonged PFS of 17 months versus 11.6 months (HR, 0.56; 95% CI, 0.36\u20100.89; <jats:italic>P<\/jats:italic> = .01). The XPF\/<jats:italic>ERCC4<\/jats:italic> (rs12926685) cytidine\u2010thymidine (CT)\/CC genotype versus the TT genotype was associated with a prolonged PFS of 16.7 months versus 12.4 months (HR, 0.63; 95% CI, 0.41\u20100.95; <jats:italic>P<\/jats:italic> = .03). On multivariate analysis adjusting for breast cancer (BRCA) gene and cytoreductive surgery status, the <jats:italic>XPC<\/jats:italic> SNPs remained significantly associated with prolonged PFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The current results indicated that <jats:italic>XPC<\/jats:italic> is a key component of the NER pathway that participates in DNA damage repair. SNPs in the <jats:italic>XPC<\/jats:italic> gene may represent novel markers of ovarian cancer response to platinum\u2010based chemotherapy. Cancer 2012;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26329","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T17:06:09Z","timestamp":1310490369000},"page":"689-697","source":"Crossref","is-referenced-by-count":32,"title":["Xeroderma pigmentosum complementation group C single\u2010nucleotide polymorphisms in the nucleotide excision repair pathway correlate with prolonged progression\u2010free survival in advanced ovarian cancer"],"prefix":"10.1002","volume":"118","author":[{"given":"Nicole D.","family":"Fleming","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasmik","family":"Agadjanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoorig","family":"Nassanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Orsulic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth Y.","family":"Karlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine S.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,12]]},"reference":[{"volume-title":"Facts & Figures 2010","year":"2010","author":"American Cancer Society","key":"e_1_2_6_2_2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00444.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.7-suppl_5-20"},{"key":"e_1_2_6_5_2","first-page":"1439","article-title":"Mechanism of action of 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