{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:17:10Z","timestamp":1791037030444,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T00:00:00Z","timestamp":1314230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>It is unclear whether women with ductal carcinoma in situ (DCIS), like their counterparts with invasive breast cancer, warrant genetic risk assessment and testing on the basis of high\u2010risk variables. The authors of this report identified predictive factors for mutations in the breast cancer\u2010susceptibility genes <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> in women who were diagnosed with DCIS.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>One hundred eighteen women with DCIS who were referred for genetic counseling and underwent genetic testing for <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>BRCA2<\/jats:italic> mutations between 2003 and 2010 were included in the study. Logistic regression models were fit to determine the associations between potential predictive factors and BRCA status.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Of 118 high\u2010risk women with DCIS, 27% (n = 32) tested positive for <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>BRCA2<\/jats:italic> mutations. Of those, 10% (n = 12) and 17% (n = 20) had <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> mutations, respectively. Age, race, and tumor characteristics did not differ between BRCA noncarriers and carriers. In a multivariate logistic model, \u22652 relatives with ovarian cancer (OC) (odds ratio [OR], 8.81; 95% confidence interval [CI], 1.38\u201056.29; <jats:italic>P<\/jats:italic> = .034), and a score \u226510% according to the BRCAPRO mathematical model for calculating the probability that a particular family member carries a germline BRCA mutation (OR, 6.37; 95% CI, 2.23\u201018.22; <jats:italic>P<\/jats:italic> = .0005) remained as independent significant predictors for a BRCA mutation. Fifty\u2010seven percent of mutation carriers but only 25% of noncarriers underwent prophylactic mastectomy(<jats:italic>P<\/jats:italic> = .0037). This difference remained significant for patients aged \u226440 years (<jats:italic>P<\/jats:italic> = .025).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Women who had DCIS and a family history of OC or who had BRCAPRO scores \u226510% had a high rate of BRCA positivity regardless of age at diagnosis. These findings suggest that high\u2010risk patients with DCIS are appropriate candidates for genetic testing for BRCA mutations in the presence of predictive factors even if they do not have invasive breast cancer. Cancer 2011;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26428","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T22:37:42Z","timestamp":1314830262000},"page":"1515-1522","source":"Crossref","is-referenced-by-count":22,"title":["Predictive factors for <i>BRCA1<\/i>\/<i>BRCA2<\/i> mutations in women with ductal carcinoma in situ"],"prefix":"10.1002","volume":"118","author":[{"given":"Soley","family":"Bayraktar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisreen","family":"Elsayegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica M.","family":"Gutierrez 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