{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:17:25Z","timestamp":1778609845000,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T00:00:00Z","timestamp":1314230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Axillary lymph node status is one of the most powerful prognostic indicators in patients with breast cancer and has implications for adjuvant treatment. It has been demonstrated that enhanced histologic evaluation of axillary lymph nodes, including serial sectioning of paraffin tissue blocks and immunohistochemical (IHC) staining, increases the rate of detection of occult metastases. The clinical significance of occult lymph node metastases has been the subject of debate.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>In the current study, the authors identified 267 patients who underwent axillary lymph node dissection (ALND) between 1987 and 1995 and were lymph node negative according to a routine pathologic evaluation, which included the complete submission of all lymph nodes and an examination of 1 hematoxylin and eosin (H&amp;E)\u2010stained section per paraffin block. Patients did not receive systemic chemotherapy or hormone therapy. All of the dissected lymph nodes from these patients were re\u2010evaluated by intensified pathologic methods (serial sectioning with H&amp;E levels plus IHC). Occult metastases were categorized by detection method and size. The clinical significance of the occult metastases was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Thirty\u2010nine patients (15%) who had lymph node\u2010negative results on routine evaluation of their ALND specimens had occult metastases identified. Eight of these patients (20%) had macrometastases &gt;2.0 mm, 15 (40%) had micrometastases (range, &gt;0.2 mm to \u22642 mm), and 16 (40%) had isolated tumor cells (\u22640.2 mm). The presence of occult metastases and the size of metastases did not affect recurrence\u2010free or overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The presence of occult metastasis did not have clinical significance in this cohort of patients with early stage breast cancer. Cancer 2011;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26458","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T22:34:47Z","timestamp":1314830087000},"page":"1507-1514","source":"Crossref","is-referenced-by-count":10,"title":["Occult axillary lymph node metastases do not have prognostic significance in early stage breast cancer"],"prefix":"10.1002","volume":"118","author":[{"given":"Yun","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Mittendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Kelten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan 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