{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:00:11Z","timestamp":1762542011878,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T00:00:00Z","timestamp":1316476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The objective of this secondary analysis was to identify patients with selected stage IIIB\/IV nonsmall cell lung carcinoma and good performance status who were at high risk for requiring subsequent palliative thoracic radiotherapy after initial treatment with first\u2010line chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The authors conducted a pooled analysis of patients at a single institution who enrolled onto 10 prospective phase 2 and 3 clinical trials that involved first\u2010line, platinum\u2010based chemotherapy. Baseline lung\u2010related characteristics before trial enrollment were analyzed as possible prognostic factors for freedom from pulmonary events (defined either as subsequent thoracic radiation or as a new collapsed lung, which is an indication for thoracic radiation).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Of 244 consecutive patients who were reviewed, 42 patients received a palliative course of thoracic radiation, 40 exhibited evidence of new lobar collapse on follow\u2010up chest imaging, and 14 received thoracic radiation for lobar collapse. On univariable analysis, pulmonary symptoms (<jats:italic>P<\/jats:italic> = .043) or pneumonia at presentation (<jats:italic>P<\/jats:italic> = .0001), increasing size of hilar disease (<jats:italic>P<\/jats:italic> &lt; .0001), and evidence of obstruction of major bronchi or vessels (<jats:italic>P<\/jats:italic> = .0003) were associated with subsequent pulmonary events. On multivariable analysis, hilar disease measuring &gt;3 cm (hazard ratio, 1.8; <jats:italic>P<\/jats:italic> = .003) and prechemotherapy pneumonia (hazard ratio, 2.1; <jats:italic>P<\/jats:italic> = .009) were associated with pulmonary events; patients who had both risk factors or hilar disease &gt;5 cm in greatest dimension exhibited a &gt;50% risk of subsequent events.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Patients with bulky hilar disease and a history of pneumonia at presentation were at high risk for requiring palliative thoracic radiation. The authors propose studying these patients to determine whether early thoracic radiation may be beneficial by preserving quality of life and performance status. Cancer 2011. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26495","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T16:04:32Z","timestamp":1316534672000},"page":"2744-2751","source":"Crossref","is-referenced-by-count":6,"title":["Predicting the need for palliative thoracic radiation after first\u2010line chemotherapy for advanced nonsmall cell lung carcinoma"],"prefix":"10.1002","volume":"118","author":[{"given":"Daniel S.","family":"Higginson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald C.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Halle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian G.","family":"Rosenman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Socinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence B.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.020164"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-5002(95)00430-9"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.1405"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318200f9c5"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61497-5"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70112-1"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.163"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.10.2095"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050753"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.5.1335"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2123"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1586\/era.10.22"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.06.019"},{"key":"e_1_2_7_15_2","first-page":"CD002143","article-title":"Palliative radiotherapy regimens for non\u2010small cell lung cancer","volume":"4","author":"Lester JF","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.3312"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/90.4.688"},{"volume-title":"AJCC Cancer Staging Manual","year":"2009","author":"Edge SB","key":"e_1_2_7_18_2"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.12.2354"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181fff142"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7362.465"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.03.028"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj016"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp352"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357900903286958"},{"issue":"15","key":"e_1_2_7_27_2","article-title":"Randomized phase II trial of erlotinib (E) alone or in combination with carboplatin\/paclitaxel (CP) in never or light former smokers with advanced lung adenocarcinoma: CALGB 30406","volume":"28","author":"Janne PA","year":"2010","journal-title":"J Clin Oncol"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn745"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181fd42eb"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.0616"},{"issue":"18","key":"e_1_2_7_31_2","article-title":"Results of a randomized, phase III trial of nab\u2010paclitaxel (nab\u2010P) and carboplatin (C) compared with cremophor\u2010based paclitaxel (P) and carboplatin as first\u2010line therapy in advanced non\u2010small cell lung cancer (NSCLC)","volume":"28","author":"Socinski MA","year":"2010","journal-title":"J Clin Oncol"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.26495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.26495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:36:25Z","timestamp":1760279785000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.26495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,20]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,5,15]]}},"alternative-id":["10.1002\/cncr.26495"],"URL":"https:\/\/doi.org\/10.1002\/cncr.26495","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2011,9,20]]}}}