{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:10:15Z","timestamp":1777529415530,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T00:00:00Z","timestamp":1319155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Malignant mesothelioma (MM) is an aggressive cancer of serosal membranes, mostly pleura. It is related to asbestos exposure and its incidence in most industrialized countries is projected to remain stable or to increase until 2020. Prognosis remains poor. Clinical prognostic scoring systems lack precision. No prognostic tissue markers are available. Aquaporin 1 (AQP1) is a cell membrane channel involved in water transport, cell motility, and proliferation. A blocker and an agonist are available.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Two independent cohorts of MM were studied. Cohort 1 consisted of 80 consecutive patients who underwent radical surgery (extrapleural pneumonectomy [EPP]). Cohort 2 included 56 conservatively managed patients from another institution. Clinical information was obtained from files. Diagnoses were histologically verified. Immunohistochemical labeling for AQP1 was performed on tumor tissue and the percentage of positive cells was scored.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>We demonstrated expression of AQP1 in normal and neoplastic mesothelium at the apical aspect of the cell, in keeping with a role in water transport. For both cohorts, expression of AQP1 by \u226550% of tumor cells was associated with significantly enhanced survival (9.4 months vs 30.4 months in EPP patients and 5 months vs 15 months in conservatively treated patients). This was independent of established prognostic factors, including histologic subtype, pathologic stage, sex, and age at time of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION:<\/jats:title><jats:p>Expression of AQP1 correlated significantly with prognosis in MM, irrespective of treatment or established prognostic factors. Immunohistochemical labeling for AQP1 should be included in the routine histopathologic workup. An agonist or blocker may become useful for treatment. <jats:bold><jats:italic>Cancer<\/jats:italic> 2011;.<\/jats:bold> \u00a9 <jats:italic>2011 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26497","type":"journal-article","created":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T10:39:45Z","timestamp":1319193585000},"page":"2952-2961","source":"Crossref","is-referenced-by-count":41,"title":["Aquaporin 1 is an independent prognostic factor in pleural malignant mesothelioma"],"prefix":"10.1002","volume":"118","author":[{"given":"Steven Chuan\u2010Hao","family":"Kao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget","family":"Condon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Griggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"McCaughan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Maltby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Klebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70471-X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67025-0"},{"key":"e_1_2_7_4_2","volume-title":"The incidence of mesothelioma in Australia 1997 to 1999: Australian Mesothelioma Register report 2002","author":"National Occupational Health and Safety Commission","year":"2002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.10047"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1586\/era.09.2"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6255"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-008-0118-6"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.58.030196.003155"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/ann.34.3.192.200"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.278.5.L867"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01171.2001"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.01.029"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118659"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2003.08.001"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.6.C1744"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0303-9"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05244.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2001.14.7.858424"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6793-2-4"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006554"},{"key":"e_1_2_7_22_2","unstructured":"GordonGJ. Expression profiling of malignant mesothelioma.http:\/\/www.ncbi.nlm.nih.gov\/geo\/gds\/profileAccessed June 6 2011."},{"key":"e_1_2_7_23_2","volume-title":"Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart","author":"Travis WD","year":"2004"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/00313020802579250"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e328342016c"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/40.11.1431060"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2245"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31822a3740"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00249.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2007.05.009"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.11.018"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23874"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.07.019"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.09.009"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.01.002"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.9275"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2873"},{"key":"e_1_2_7_38_2","unstructured":"KaoSCH KlebeS HendersonDW et al.Protein expression of excision repair cross complementation group 1 and thymidylate synthase in malignant pleural mesothelioma patients undergoing extrapleural pneumonectomy. Presented at the 14th World Conference on Lung Cancer; July 3\u20107 2011; Amsterdam Netherlands. Poster P3.307."},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02738.x"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.26497","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.26497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:54:54Z","timestamp":1760298894000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.26497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,21]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/cncr.26497"],"URL":"https:\/\/doi.org\/10.1002\/cncr.26497","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,21]]}}}