{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:03:53Z","timestamp":1778144633806,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:00:00Z","timestamp":1319760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Isolated isochromosome (17q) is a rare cytogenetic abnormality in Philadelphia chromosome\u2010negative myeloid neoplasms, usually myelodysplastic and\/or myeloproliferative neoplasms (MDS\/MPN). De novo acute myeloid leukemia (AML) with isochromosome 17q has rarely been reported. The frequency of genetic mutations is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The authors assessed clinicopathologic, immunophenotypic, and molecular genetic features of 22 myeloid neoplasms with isolated isochromosome 17q.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Fourteen patients presented as MDS\/MPN; 8 as de novo AML. Most presented with leukocytosis, anemia, thrombocytopenia, and splenomegaly. Morphologically, all showed myelodysplastic and myeloproliferative features, including pseudo\u2010Pelger\u2010Huet\u2010like neutrophils, micromegakaryocytic hyperplasia, hypercellularity, fibrosis, and osteosclerosis. Blasts were increased (median, 40% in de novo AML; 9% in MDS\/MPN). Immunohistochemical assessment of proliferation and apoptosis rates in AML were similar to a matched group without isochromosome 17q. In most patients, isochromosome 17q occurred at time of blast transformation or disease progression. DNA sequencing revealed no mutation in the uninvolved <jats:italic>TP53<\/jats:italic> allele. Mutational analyses showed rare mutations in <jats:italic>NRAS<\/jats:italic> (3 of 10), <jats:italic>FLT3<\/jats:italic> (2 of 16), and <jats:italic>JAK2<\/jats:italic> (1 of 18), and no mutations in <jats:italic>NPM1<\/jats:italic> (0 of 15), <jats:italic>KIT<\/jats:italic> (0 of 4), and <jats:italic>CEBPA<\/jats:italic> (0 of 4). The median overall survival was 14.5 months for de novo AML, and 11.0 months for MDS\/MPN. With a median follow\u2010up of 8.5 months (range, 1.5\u2010107 months), 15 died of disease, 6 had persistent disease, and 1 was in remission after bone marrow transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The authors conclude that myeloid neoplasms with isolated isochromosome 17q represent a distinct clinicopathologic entity with myelodysplastic and myeloproliferative features, high risk of leukemic transformation, and wild\u2010type <jats:italic>TP53<\/jats:italic>. Cancer 2011;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26537","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T14:18:04Z","timestamp":1319811484000},"page":"2879-2888","source":"Crossref","is-referenced-by-count":66,"title":["Myeloid neoplasms with isolated isochromosome 17q represent a clinicopathologic entity associated with myelodysplastic\/myeloproliferative features, a high risk of leukemic transformation, and wild\u2010type <i>TP53<\/i>"],"prefix":"10.1002","volume":"118","author":[{"given":"Rashmi","family":"Kanagal\u2010Shamanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Bueso\u2010Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bedia","family":"Barkoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Garcia\u2010Manero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saroj","family":"Vadhan\u2010Raj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Hoehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Cameron","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01537.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V52.6.1229.1229"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197811)42:5<2254::AID-CNCR2820420525>3.0.CO;2-0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1979.tb13519.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90056-5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90114-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90113-0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90102-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90152-Z"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1182\/blood.V78.7.1652.1652","article-title":"p53 gene mutations in acute myeloid leukemia with 17p monosomy","volume":"78","author":"Fenaux P","year":"1991","journal-title":"Blood"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90073-U"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(02)00510-1"},{"key":"e_1_2_6_14_2","first-page":"659","article-title":"Exacerbation of acute leukemia bearing isolated i(17q) along with proliferation of blasts with high BMI\u20101 expression [in Japanese]","volume":"48","author":"Mihara K","year":"2007","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.11.021"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90198-0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(93)90130-D"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23977"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-0609.1990.tb00401.x","article-title":"Acute nonlymphocytic leukemia (ANLL) with isochromosome i(17q) as the sole chromosomal anomaly: a distinct entity?","volume":"44","author":"Weh HJ","year":"1990","journal-title":"Eur J Haematol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1182\/blood.V75.8.1679.1679","article-title":"Isochromosome 17q in Ph\u2010negative leukemia: a clinical cytogenetic, and molecular study","volume":"75","author":"Becher R","year":"1990","journal-title":"Blood"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(93)90080-5"},{"key":"e_1_2_6_22_2","first-page":"714","article-title":"Isochromosome 17q in patients with myelodysplastic syndromes: 6 new cases","volume":"88","author":"Xiao Z","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1182\/blood.V94.1.225.413k24_225_232","article-title":"Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP13 mutation","volume":"94","author":"Fioretos T","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_24_2","first-page":"18","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Vardiman JW","year":"2008"},{"key":"e_1_2_6_25_2","first-page":"88","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Brunning RD","year":"2008"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.01.005"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1309\/FDGWB5C2MYRYXH2E"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.170"},{"key":"e_1_2_6_29_2","first-page":"521","article-title":"Frequent p53 overexpression in therapy related myelodysplastic syndromes and acute myeloid leukemias: an immunohistochemical study of bone marrow biopsies","volume":"6","author":"Orazi A","year":"1993","journal-title":"Mod Pathol"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800026"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2009.10.014"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20732"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24610"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.89"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.8.2434"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278182"},{"key":"e_1_2_6_37_2","first-page":"458","article-title":"The localization of the human myeloperoxydase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia","volume":"1","author":"Chang KS","year":"1987","journal-title":"Leukemia"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00081-8"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.26537","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.26537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:55:02Z","timestamp":1760298902000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.26537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,28]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/cncr.26537"],"URL":"https:\/\/doi.org\/10.1002\/cncr.26537","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,28]]}}}