{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:42:29Z","timestamp":1792636949162,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T00:00:00Z","timestamp":1325548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>No previous prospective US study has examined whether the incidence of colorectal cancer (CRC) is disproportionately high in low socioeconomic status (SES) populations of both men and women. This study examined the relationship between both individual and area\u2010level SES and CRC incidence, overall and by tumor location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Data were obtained from the ongoing prospective National Institutes of Health\u2010AARP Diet and Health Study of persons (50\u201071 years old) who resided in 6 US states and 2 metropolitan areas at baseline in 1995\u20101996. Incident CRCs were ascertained from tumor registries through December 2006. SES was measured by self\u2010reported education and census\u2010tract socioeconomic deprivation. Baseline and follow\u2010up questionnaires collected detailed information on individual\u2010level CRC risk factors including family history and health behaviors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Among 506,488 participants analyzed, 7676 were diagnosed with primary invasive colorectal adenocarcinomas: 46.6% in the right colon, 26.7% in the left colon, and 25.9% in the rectum. The overall incidence of CRC was significantly higher among people who had low educational level or lived in low\u2010SES neighborhoods, relative to respective highest\u2010SES groups, even after accounting for other risk factors. These associations were stronger in the rectum than in left or right colon. In the right colon, there were no significant SES differences by either SES measure after accounting for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>SES, assessed by either individual\u2010level education or neighborhood measures, was associated with risk of CRC even after accounting for other risk factors. The relationship between SES and CRC was strongest in the rectum and weakest in the right colon. Cancer 2012;3636\u20133644. \u00a9 2012 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.26677","type":"journal-article","created":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T20:35:42Z","timestamp":1325709342000},"page":"3636-3644","source":"Crossref","is-referenced-by-count":238,"title":["Socioeconomic status and the risk of colorectal cancer"],"prefix":"10.1002","volume":"118","author":[{"given":"Chyke A.","family":"Doubeni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeyinka O.","family":"Laiyemo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Major","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Schootman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry I.","family":"Graubard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert R.","family":"Hollenbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20121"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-9684(15)31544-3"},{"key":"e_1_2_7_4_2","volume-title":"Area Socioeconomic Variations in U.S. Cancer Incidence, Mortality, Stage, Treatment, and Survival, 1975\u20101999. 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NIH Publication No. 03\u20105417","author":"Singh GK","year":"2003"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9601-y"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008950210967"},{"issue":"94","key":"e_1_2_7_7_2","first-page":"35","article-title":"Longitudinal study of socio\u2010economic differences in the incidence of stomach, colorectal and pancreatic cancers","author":"Brown J","year":"1998","journal-title":"Popul Trends."},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/83.8.551"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9256-0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25195"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.03.014"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3461"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.12.1119"},{"key":"e_1_2_7_14_2","first-page":"e1","article-title":"Health Status, Neighborhood Socioeconomic Context, and Premature Mortality in the United States: the National Institutes of Health\u2010AARP Diet and Health Study","author":"Doubeni CA","year":"2011","journal-title":"Am J Public Health."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015538"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980007000419"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn097"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531094"},{"key":"e_1_2_7_19_2","volume-title":"American Cancer Society. Colorectal Cancer Facts and Figures 2010\u20102013","year":"2011"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860310010673"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.025"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4618"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432203"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp436"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.10.037"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0104"},{"key":"e_1_2_7_27_2","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. SEER*Stat Database: Incidence\u2014SEER 17 Registries Research Data + Hurricane Katrina Impacted Louisiana Cases November 2009 Submission (1973\u20102007 varying). National Cancer Institute Division of Cancer Control and Population Sciences Surveillance Research Program Cancer Statistics Branch. Released April 2010. 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