{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:37:34Z","timestamp":1770824254391,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T00:00:00Z","timestamp":1323734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Enteropathy\u2010associated T\u2010cell lymphoma (EATL) is a rare lymphoma subtype that is strongly associated with celiac disease (CD), an autoimmune disease triggered by the ingestion of gluten. Because CD rates are increasing in the United States, the authors sought to determine whether the incidence rates of EATL also are increasing.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The authors identified patients with primary, pathologically confirmed lymphoma in the Surveillance, Epidemiology, and End Results database registries from 1973 to 2008. To ensure capture of all cases of EATL, the following lymphoma subtypes, limited to the small bowel, were included: non\u2010Hodgkin lymphoma not otherwise specified (NOS) T\u2010cell, peripheral T\u2010cell lymphoma NOS, and enteropathy type T\u2010cell lymphoma, and their age\u2010adjusted and sex\u2010adjusted incidence rates were calculated over time. Survival was estimated using Kaplan\u2010Meier curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>In total, the authors identified 161 small bowel lymphomas that were diagnosed between 1973 and 2008. The overall age\u2010adjusted and sex\u2010adjusted annual incidence for all bowel lymphomas was 0.016 per 100,000 population, which increased over the study period from 0.006 to 0.024 per 100,000 population. These tumors were most common in men (age\u2010adjusted incidence rate, 0.021 per 100,000) with the highest incidence rate in Hispanics (age\u2010adjusted incidence rate, 0.033 per 100,000). The median overall survival was 7 months. There was no difference in survival by race\/ethnicity (<jats:italic>P<\/jats:italic> = .09) or sex (<jats:italic>P<\/jats:italic> = .06).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The current results indicated a significant increase in the incidence of EATL in the United States, which may reflect the increasing seroprevalence of CD and better recognition of rare types of T\u2010cell lymphomas. The incidence may continue to rise given the large ratio of undiagnosed\u2010to\u2010diagnosed individuals with CD in the United States. Cancer 2012. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26700","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T10:22:40Z","timestamp":1323771760000},"page":"3786-3792","source":"Crossref","is-referenced-by-count":47,"title":["Increasing incidence of enteropathy\u2010associated T\u2010cell lymphoma in the United States, 1973\u20102008"],"prefix":"10.1002","volume":"118","author":[{"given":"Reem Z.","family":"Sharaiha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Lebwohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Reimers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govind","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter 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