{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:51:44Z","timestamp":1782816704926,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The objective of this study was to prospectively evaluate dynamic contrast\u2010enhanced magnetic resonance imaging (DCE\u2010MRI) as an early imaging indicator of tumor histologic response to preoperative chemotherapy and as a possible prognostic factor for event\u2010free survival (EFS) and overall survival in pediatric patients with newly diagnosed, nonmetastatic osteosarcoma who were treated on a single, multi\u2010institutional phase 2 trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Three serial DCE\u2010MRI examinations at week 0 (before treatment), week 9, and week 12 (tumor resection) were performed in 69 patients with nonmetastatic osteosarcoma to monitor the response to preoperative chemotherapy. Four DCE\u2010MRI kinetic parameters (the influx volume transfer constant [<jats:italic>K<\/jats:italic><jats:sup><jats:italic>trans<\/jats:italic><\/jats:sup>], the efflux rate constant [<jats:italic>k<\/jats:italic><jats:sub><jats:italic>ep<\/jats:italic><\/jats:sub>], the relative extravascular extracellular space [<jats:italic>v<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub>], and the relative vascular plasma space [<jats:italic>v<\/jats:italic><jats:sub><jats:italic>p<\/jats:italic><\/jats:sub>]) and the corresponding differences (\u0394<jats:italic>K<\/jats:italic><jats:sup><jats:italic>trans<\/jats:italic><\/jats:sup>, \u0394<jats:italic>k<\/jats:italic><jats:sub><jats:italic>ep<\/jats:italic><\/jats:sub>, \u0394<jats:italic>v<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub>, and \u0394<jats:italic>v<\/jats:italic><jats:sub><jats:italic>p<\/jats:italic><\/jats:sub>) of averaged kinetic parameters between the outer and inner halves of tumors were calculated to assess their associations with tumor histologic response, EFS, and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The parameters <jats:italic>K<\/jats:italic><jats:sup><jats:italic>trans<\/jats:italic><\/jats:sup>, <jats:italic>v<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub>, <jats:italic>v<\/jats:italic><jats:sub><jats:italic>p<\/jats:italic><\/jats:sub>, and <jats:italic>k<\/jats:italic><jats:sub><jats:italic>ep<\/jats:italic><\/jats:sub> decreased significantly from week 0 to week 9 and week 12. The parameters <jats:italic>K<\/jats:italic><jats:sup><jats:italic>trans<\/jats:italic><\/jats:sup>, <jats:italic>v<\/jats:italic><jats:sub><jats:italic>p<\/jats:italic><\/jats:sub>, and \u0394<jats:italic>k<\/jats:italic><jats:sub><jats:italic>ep<\/jats:italic><\/jats:sub> at week 9 were significantly different between responders and nonresponders (<jats:italic>P<\/jats:italic> = .046, <jats:italic>P<\/jats:italic> = .021, and <jats:italic>P<\/jats:italic> = .008, respectively). These 3 parameters were indicative of histologic response. The parameter \u0394<jats:italic>v<\/jats:italic><jats:sub><jats:italic>e<\/jats:italic><\/jats:sub> at week 0 was a significant prognostic factor for both EFS (<jats:italic>P<\/jats:italic> = .02) and overall survival (<jats:italic>P<\/jats:italic> = .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>DCE\u2010MRI was identified as a prognostic factor for EFS and overall survival before treatment on this trial and was indicative of a histologic response to neoadjuvant therapy. Further studies are needed to verify these findings with other treatment regimens and establish the potential role of DCE\u2010MRI in the development of risk\u2010adapted therapy for osteosarcoma. Cancer 2012. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26701","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T11:16:15Z","timestamp":1324034175000},"page":"3776-3785","source":"Crossref","is-referenced-by-count":92,"title":["Dynamic contrast\u2010enhanced magnetic resonance imaging as a prognostic factor in predicting event\u2010free and overall survival in pediatric patients with osteosarcoma"],"prefix":"10.1002","volume":"118","author":[{"given":"Junyu","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilburn E.","family":"Reddick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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