{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:50:29Z","timestamp":1761519029132,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Aldehyde dehydrogenase 1 (ALDH1)\u2010positive cells exhibit stem\u2010like or progenitor ability and have been considered a clinically important diagnostic and therapeutic target in patients with breast cancer. In this study, the authors evaluated responsiveness to chemotherapy of ALDH1\u2010positive cells in primary and metastatic lesions and its relation to prognosis for patients with lymph node\u2010positive breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>In total, 115 patients who had breast cancer with cytologically confirmed lymph node metastases and who underwent surgery after neoadjuvant chemotherapy (NAC) were evaluated. By using ALDH1 immunohistochemistry in core\u2010needle biopsy specimens of the primary tumor, cytology samples of axillary lymph nodes before NAC, and pathologic samples of each after NAC, the clinical significance of ALDH1\u2010positive cell status was evaluated in primary and metastatic lesions before and after NAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The presence of ALDH1\u2010positive cancer cells, but not ALDH1\u2010negative cancer cells, in primary and metastatic lesions after NAC was associated with a worse prognosis. In multivariate analysis, only ALDH1\u2010positive cells in metastatic lesions after NAC correlated with overall survival. The responsiveness of ALDH1\u2010positive cells to chemotherapy differed between primary and metastatic lesions, and the findings indicated that ALDH1\u2010positive cells in metastatic lesions after NAC may clinically precede those in the primary lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The responsiveness of ALDH1\u2010positive cells to chemotherapy in primary and metastatic lesions and its prognostic significance were clarified in patients with breast cancer. The authors concluded that ALDH1\u2010positive status may represent a surrogate marker as a new concept in patients with lymph node\u2010positive breast cancer. Cancer 2012. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26725","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T10:40:24Z","timestamp":1324032024000},"page":"3899-3910","source":"Crossref","is-referenced-by-count":23,"title":["Aldehyde dehydrogenase 1\u2010positive cells in axillary lymph node metastases after chemotherapy as a prognostic factor in patients with lymph node\u2010positive breast 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