{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:46:15Z","timestamp":1790142375265,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Acute lymphoblastic leukemia (ALL) occurring in patients with a history of prior chemotherapy\/radiotherapy exposure has been previously reported to be rare, accounting for &lt;2.5% of ALL cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>All cases of adult ALL with a history of prior cytotoxic or radiation therapy at a leukemia referral center over a 13\u2010year period were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Twenty\u2010three cases, representing 6.9% of all ALL cases, were identified. Of these, 17 (74%) had at least 1 high\u2010risk feature; 8 (35%) had <jats:italic>MLL<\/jats:italic> rearrangements, and 4 were <jats:italic>BCR\u2010ABL<\/jats:italic><jats:sup>+<\/jats:sup>. <jats:italic>MLL<\/jats:italic> rearrangements were correlated with CD15 expression and absence of CD10, and also tended to have a shorter mean latency period and more prior topoisomerase II exposure. Twenty\u2010one patients received induction therapy, and 18 (86%) achieved a complete response, 17 with 1 induction. Six patients have relapsed and died, and 4 others died of other complications, 2 of these postallogeneic stem cell transplantation. Median disease\u2010free survival (DFS) and overall survival (OS) were 27 and 13.6 months, respectively, and 3\u2010year DFS and OS were 37.1% and 37.6%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The frequency of therapy\u2010related ALL is higher than previously reported and has a poor prognosis, probably related to the high frequency of adverse risk features. Cancer 2012. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26735","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T11:06:50Z","timestamp":1324033610000},"page":"3962-3967","source":"Crossref","is-referenced-by-count":48,"title":["Therapy\u2010related acute lymphoblastic leukemia is more frequent than previously recognized and has a poor prognosis"],"prefix":"10.1002","volume":"118","author":[{"given":"Amal","family":"Abdulwahab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Kamel\u2010Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Brandwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02527.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3343"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp232"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902043400504"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3035"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009113377"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402918"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPYWC6AQC7BAVJ"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.06.001"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0092"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-150680"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07712.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20668"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn182"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200058"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404420"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.26735","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.26735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:09:38Z","timestamp":1760281778000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.26735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,16]]},"references-count":16,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2012,8,15]]}},"alternative-id":["10.1002\/cncr.26735"],"URL":"https:\/\/doi.org\/10.1002\/cncr.26735","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,16]]}}}