{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:19:38Z","timestamp":1790882378682,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:00:00Z","timestamp":1329868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The authors report preliminary results from a prospective multicenter study (Nasopharyngeal Carcinoma [NPC] 2003 German Society of Pediatric Oncology and Hematology\/German Children's Oncology Group [NPC\u20102003\u2010GPOH\/DCOG]).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>From 2003 to 2010, 45 patients (ages 8\u201020 years), including 1 patient with stage II NPC and 44 patients with stage III\/IV NPC, were recruited to the study. The patient with stage II disease received radiotherapy (59.4 grays [Gy]). The patients with stage III\/IV disease received 3 courses of neoadjuvant chemotherapy with cisplatin, 5\u2010fluorouracil, and folinic acid. The cumulative irradiation dose was 54 Gy in 5 patients, who achieved complete remission after neoadjuvant chemotherapy, and 59.4 Gy in the remaining 40 patients. All patients received concomitant cisplatin during the first week and last week of irradiation. After irradiation, all patients received interferon beta for 6 months. Tumor response was evaluated by magnetic resonance imaging studies and positron emission tomography scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>After the completion of treatment, 43 of 45 patients were in complete remission. In 2 patients, only a partial response was achieved, followed by distant metastases (1 patient) or local progression and distant metastases (1 patient), 6 months and 10 months after diagnosis, respectively. Another patient developed a solitary pelvic bone metastasis 21 months after diagnosis. After a median follow\u2010up of 30 months (range, 6\u201095 months), the event\u2010free survival rate was 92.4%, and the overall survival was 97.1%. Acute toxicity consisted mainly of leucopenia, mucositis, and nausea; and late toxicity consisted of hearing loss and hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Combined therapy with neoadjuvant chemotherapy, radiochemotherapy, and interferon beta was well tolerated and resulted in a very good outcome that was superior to the outcomes of published results from all other pediatric NPC study groups. Cancer 2012. \u00a9 2012 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.27395","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T12:40:37Z","timestamp":1329914437000},"page":"4892-4900","source":"Crossref","is-referenced-by-count":110,"title":["Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults"],"prefix":"10.1002","volume":"118","author":[{"given":"Martina","family":"Buehrlen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Michel","family":"Zwaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Granzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Lassay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Deutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vorwerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gundula","family":"Staatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Gademann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foppe","family":"Oldenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Tamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-0911-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-23"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)00956-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170102"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11485"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181626cfe"},{"key":"e_1_2_6_8_2","article-title":"Long\u2010term outcomes of early\u2010stage nasopharyngeal carcinoma patients treated with intensity\u2010modulated radiotherapy alone [published online ahead of print October 28, 2010]","author":"Su SF","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.037"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e328337160e"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25376"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21258"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20823"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.00872.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000217243.08756.0c"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2010.01.003"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000183271.22947.64"},{"key":"e_1_2_6_18_2","first-page":"723","article-title":"Clinical and prognostic analysis of nasopharyngeal carcinoma in 44 children and adolescents","volume":"33","author":"Hong J","year":"2008","journal-title":"Zhong Nan Da Xue Bao Yi Xue Ban."},{"key":"e_1_2_6_19_2","first-page":"977","article-title":"Nasopharyngeal carcinoma in Tunesian children: retrospective epidemiological, clinical and biological study about 48 cases","volume":"92","author":"Jmal A","year":"2005","journal-title":"Bull Cancer."},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.01.032"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21372"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2009.07.005"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860601016062"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.05.028"},{"key":"e_1_2_6_25_2","unstructured":"American Joint Committee on Cancer. AJCC Cancer Staging Manual past editions. Available from:http:\/\/www.cancerstaging.org\/products\/pasteditions.html. Accessed January 5 2011."},{"key":"e_1_2_6_26_2","volume-title":"WHO Handbook for Reporting Results of Cancer Treatment. Offset Publication No. 48","author":"World Health Organization (WHO)","year":"1979"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91308-2"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_6_29_2","volume-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch JD","year":"1980"},{"key":"e_1_2_6_30_2","volume-title":"SAS [computer program]","author":"SAS Institute, Inc.","year":"2011"},{"key":"e_1_2_6_31_2","volume-title":"R, version 2.12.1 [computer program]","author":"R Foundation for Statistical Computing","year":"2011"},{"key":"e_1_2_6_32_2","unstructured":"National Cancer Institute. Stage Information for nasopharyngeal cancer. Available from:http:\/\/www.cancer.gov\/cancertopics\/pdq\/treatment\/nasopharyngeal\/HealthProfessional\/page3. Accessed January 30 2011."},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3282fad846"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e328333e3ef"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.028"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1784-9"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0729-7"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970901)80:5<951::AID-CNCR18>3.0.CO;2-V"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0640-2"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.081"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.9109"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.12.003"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.6195"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e3181f3cbf4"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2975"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-008-9093-8"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.27395","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.27395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T23:59:28Z","timestamp":1760313568000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.27395"}},"subtitle":["Preliminary results from the prospective, multicenter study NPC\u20102003\u2010GPOH\/DCOG"],"short-title":[],"issued":{"date-parts":[[2012,2,22]]},"references-count":45,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1002\/cncr.27395"],"URL":"https:\/\/doi.org\/10.1002\/cncr.27395","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,22]]}}}