{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:29:07Z","timestamp":1790357347841,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T00:00:00Z","timestamp":1338249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) may prevent the development of cancer by inhibiting cyclooxygenase (COX) enzymes, which are involved in carcinogenesis. Therefore, the authors of this report examined the association between NSAID use and the risk of squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and malignant melanoma (MM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>From 1991 through 2009, all incident cases of SCC (n = 1974), BCC (n = 13,316), and MM (n = 3242) in northern Denmark were identified. Approximately 10 population controls (n = 178,655) were matched to each case by age, gender, and county of residence. The use of aspirin, other nonselective NSAIDs, or selective COX\u20102 inhibitors was ascertained through a prescription database. Conditional logistic regression analyses adjusted for potential confounders were used to compute odds ratios as estimates of incidence rate ratios (IRRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>For NSAIDs overall, ever use (&gt;2 prescriptions) compared with nonuse (\u22642 prescriptions) was associated with a decreased risk of SCC (IRR, 0.85; 95% confidence interval [CI], 0.76\u20100.94) and MM (IRR, 0.87; 95% CI, 0.80\u20100.95), especially for long\u2010term use (\u22657 years) and high\u2010intensity use (&gt;25% prescription coverage during the total duration of use). NSAID use was not associated with a reduced risk of BCC overall (IRR, 0.97; 95% CI, 0.93\u20101.01), but the risk of BCC at sites other than the head and neck was reduced in association with long\u2010term use (IRR, 0.85; 95% CI, 0.76\u20100.95) and high\u2010intensity use (IRR, 0.79; 95% CI, 0.69\u20100.91). All estimates of reduced risk were driven primarily by the use of nonselective NSAIDs and older COX\u20102 inhibitors (diclofenac, etodolac, and meloxicam).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The current results indicated that NSAID use may decrease the risk of SCC and MM. Cancer 2012. \u00a9 2012 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.27406","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T10:04:00Z","timestamp":1338285840000},"page":"4768-4776","source":"Crossref","is-referenced-by-count":84,"title":["Nonsteroidal anti\u2010inflammatory drugs and the risk of skin cancer"],"prefix":"10.1002","volume":"118","author":[{"given":"Sigrun Alba","family":"Johannesdottir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen T.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Mehnert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Braae","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071364"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30407.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.05.049"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.374"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn154"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1718"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.58"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq442"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31703"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.201"},{"key":"e_1_2_6_12_2","first-page":"655","article-title":"Inverse association of non\u2010steroidal anti\u2010inflammatory drugs and malignant melanoma among women","volume":"8","author":"Harris RE","year":"2001","journal-title":"Oncol Rep."},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21878"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.05.042"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S13458"},{"key":"e_1_2_6_16_2","unstructured":"Danish Medicines Agency. 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