{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:12:39Z","timestamp":1787807559008,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003645","name":"National Cancer Center, Korea","doi-asserted-by":"crossref","award":["NCC 1010190"],"award-info":[{"award-number":["NCC 1010190"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Endoscopy screening in high\u2010risk populations may reduce gastric cancer mortality by detecting cancer earlier. We evaluated the association between the interval between upper gastrointestinal endoscopies and the gastric cancer stage at diagnosis in patients from a region of high prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The study cohort consisted of 2485 patients diagnosed with gastric adenocarcinoma. We evaluated the effect on cancer stage of the interval between the endoscopy that was diagnostic for gastric cancer and the endoscopy preceding it. Patients were stratified into 7 groups: 1\u2010, 2\u2010, 3\u2010, 4\u2010, 5\u2010, &gt;5\u2010year intervals and those who were never screened.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The risk of higher cancer stage at diagnosis increased by 23% per increase in interval length (odds ratio = 1.23, 95% confidence interval [CI] = 1.19\u20101.28). Compared to the never\u2010screened, the odds ratio of having a higher stage of cancer decreased gradually from 0.53 (95% CI = 0.41\u20100.69) in the &gt;5\u2010year interval group to 0.31 (95% CI = 0.24\u20100.40) in the 1\u2010year interval group. Compared to the 1\u2010year interval group, the risk of advanced gastric cancer was increased in the 4\u2010 and 5\u2010year, but not the 2\u2010 and 3\u2010year, interval groups. However, patients with a family history of gastric cancer were more likely to have a higher stage at diagnosis if they had a 3\u2010year interval rather than a 1\u2010year interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>A significant benefit in cancer stage at diagnosis was observed in all interval groups compared to never\u2010screened. Endoscopy intervals of 3 years or less showed similar benefits, but family members of gastric cancer patients may benefit from intervals of under 3 years. Cancer 2012. \u00a9 2012 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.27495","type":"journal-article","created":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T09:05:28Z","timestamp":1342429528000},"page":"4953-4960","source":"Crossref","is-referenced-by-count":48,"title":["Association of the interval between endoscopies with gastric cancer stage at diagnosis in a region of high prevalence"],"prefix":"10.1002","volume":"118","author":[{"given":"Ji Hyung","family":"Nam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Ju","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Jeong","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Gyoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kwan","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui Son","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Ho","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Won","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181ca69a7"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70072-X"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.19.935"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318185e62e"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn017"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0940"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2006.07.016"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21664"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328318ed42"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802085395"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2001.0925"},{"key":"e_1_2_7_14_2","first-page":"65","volume-title":"TNM classification of malignant tumours","author":"International Union Against Cancer (UICC)","year":"2002"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011681"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011692"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0027"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011735"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10646"},{"key":"e_1_2_7_21_2","first-page":"11","article-title":"Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients","volume":"16","author":"Sasao S","year":"2006","journal-title":"Oncol Rep"},{"key":"e_1_2_7_22_2","first-page":"321","article-title":"An endoscopic view in gastric linitis. A case report","volume":"16","author":"Negreanu L","year":"2007","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_7_23_2","first-page":"337","article-title":"Study of survival and prognostic factors in patients undergoing resection for gastric linitis plastica: a review of 86 cases","volume":"84","author":"Hamy A","year":"1999","journal-title":"Int Surg"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605380"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101634"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05314.x"},{"key":"e_1_2_7_27_2","first-page":"513","article-title":"Screening for cancer: evaluating the evidence","volume":"63","author":"Gates TJ","year":"2001","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5600"},{"key":"e_1_2_7_29_2","first-page":"888","volume-title":"Sleisenger and Fordtran's Gastrointestinal and Liver Disease; Pathophysiology\/Diagnosis\/Management","author":"Abrams JA","year":"2010"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<921::AID-CNCR24>3.0.CO;2-S"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25550"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.618"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-13685"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.27495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.27495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:16:51Z","timestamp":1760282211000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.27495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,16]]},"references-count":32,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2012,10,15]]}},"alternative-id":["10.1002\/cncr.27495"],"URL":"https:\/\/doi.org\/10.1002\/cncr.27495","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,16]]}}}