{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:14:45Z","timestamp":1785413685569,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The objective of this study was to identify the prognostic factors for hearing preservation that would allow the more accurate stratification of patients who undergo stereotactic radiosurgery (SRS) for unilateral, sporadic vestibular schwannoma (VS).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>In total, 119 patients with VS who had serviceable hearing underwent SRS as primary treatment. The mean (\u00b1standard deviation) patient age was 48 \u00b1 11 years, and the mean (\u00b1standard deviation) follow\u2010up duration was 55.2 \u00b1 35.7 months. The median marginal radiotherapy dose was 12.0 grays (Gy), and the mean (\u00b1standard deviation) tumor volume was 1.95 \u00b1 2.24 cm<jats:sup>3<\/jats:sup>. The mean (\u00b1standard deviation) pure tone average (PTA) score was 26 \u00b1 12 decibels (dB) (range, 4\u201050 dB), and the mean (\u00b1standard deviation) maximum speech discrimination score was 91 \u00b1 12% (range, 52\u2010100%). The mean (\u00b1standard deviation) baseline values for the interlatency (IL) of waves I and III (IL I\u2010III) and the IL of waves I through V (IL I\u2010V) on auditory brainstem response were 2.58 \u00b1 0.60 milliseconds (mS) (range, 1.92\u20104.30 mS) and 4.80 \u00b1 0.61 mS (range, 3.80\u20106.40 mS), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>In multivariate analysis, the PTA score and IL I\u2010V were significant and independent prognostic factors (hazard ratio, 1.072; 95% confidence interval, 1.046\u20101.098; <jats:italic>P<\/jats:italic> &lt; .001; and hazard ratio, 1.534; 95% confidence interval, 1.008\u20102.336; <jats:italic>P<\/jats:italic> = .046, respectively). By using the PTA score and IL I\u2010V, the patients were classified into 4 groups. The ratios of patients with serviceable hearing after SRS were 89.6%, 64.0%, 25.8%, and 6.7%, respectively, in Groups A through D (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The current results indicated that the classification system based on using the PTA score and the IL I\u2010V of the auditory brainstem response may be useful and specific for predicting the rate of hearing preservation in each individual. Cancer 2012. \u00a9 2012 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.27501","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T13:59:37Z","timestamp":1336485577000},"page":"5441-5447","source":"Crossref","is-referenced-by-count":19,"title":["Hearing preservation in patients with unilateral vestibular schwannoma who undergo stereotactic radiosurgery"],"prefix":"10.1002","volume":"118","author":[{"given":"Jung Ho","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Gyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Tai","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun 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