{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:57:12Z","timestamp":1792709832168,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to examine prospectively the utility of adding preoperative [\n                      <jats:sup>18<\/jats:sup>\n                      F]fluorodeoxyglucose positron emission tomography (FDG\u2010PET)\/computed tomography (CT) to routine CT, endoscopic ultrasound (EUS), and laparoscopic staging of localized gastric cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Patients with locally advanced gastric\/gastroesophageal cancer were screened for 2 institutional review board\u2013approved Memorial Sloan\u2010Kettering Cancer Center neoadjuvant chemotherapy protocols. Locally advanced disease was defined as T3 or T4, or lymph node\u2013positive, based on EUS and high\u2010resolution CT scan. All patients underwent both standard FDG\u2010PET\/CT and laparoscopy with cytological examination of washings. The sensitivity and specificity of FDG\u2010PET\/CT for the identification of metastatic disease not seen on CT was determined. An economic model using Medicare\/Medicaid reimbursement charges was developed to assess the cost\u2010effectiveness of these interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of 113 patients were enrolled from 2003 to 2010. All patients were assessed as having locally advanced disease by CT\/EUS. FDG uptake in the primary tumor was associated with male sex, proximal tumors, and nondiffuse Lauren's subtype. 31 (27%) patients had occult metastatic disease detected by PET\/CT (n = 11, 10%) and\/or laparoscopy (n = 21, 19%), with a single overlap. Economic modeling suggests that the addition of FDG\u2010PET\/CT to the standard staging evaluation of patients with locally advanced gastric cancer resulted in an estimated cost savings of \u223cUS $13,000 per patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>FDG\u2010PET\/CT identifies occult metastatic lesions in approximately 10% of patients with locally advanced gastric cancer. Because of reduced morbidity from fewer futile surgeries and lower patient care costs, PET\/CT should be considered as a component of the standard staging algorithm for localized gastric cancer. Cancer 2012. \u00a9 2012 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.27550","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T00:48:17Z","timestamp":1335919697000},"page":"5481-5488","source":"Crossref","is-referenced-by-count":122,"title":["A prospective evaluation of the utility of 2\u2010deoxy\u20102\u2010[\n                    <sup>18<\/sup>\n                    F]fluoro\u2010\n                    <scp>D<\/scp>\n                    \u2010glucose positron emission tomography and computed tomography in staging locally advanced gastric cancer"],"prefix":"10.1002","volume":"118","author":[{"given":"Elizabeth","family":"Smyth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Sch\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian E.","family":"Strong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinela","family":"Capanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Kelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Coit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish 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