{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:13:50Z","timestamp":1790673230420,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T00:00:00Z","timestamp":1350950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Many patients who require allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) lack a human leukocyte antigen (HLA)\u2010matched donor. Recently, a new strategy was developed for HLA\u2010mismatched\/haploidentical transplantation from family donors without in vitro T cell depletion (TCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Over the past 9 years, 756 patients underwent haploidentical transplantation using a protocol developed by the authors, which combines granulocyte\u2010colony stimulating factor\u2013primed bone marrow (G\u2010BM) and peripheral blood stem cells without in vitro TCD. The long\u2010term outcome with this treatment modality was reported, and a risk\u2010factor analysis was provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Of these patients, 752 (99%) achieved sustained, full donor chimerism. The incidence of grades 2 through 4 acute graft\u2010versus\u2010host disease (GVHD) was 43%, and the 2\u2010year cumulative incidence of total chronic GVHD was 53%. The 3\u2010year cumulative incidence of nonrelapse mortality was 18%. The 2\u2010year cumulative incidences of relapse were 15% and 26% in the standard\u2010risk and high\u2010risk groups, respectively. Of the 756 patients, 480 survived throughout the follow\u2010up period of 1154 days (range: 335\u20103511 days) with the 3\u2010year leukemia\u2010free survival rates of 68% and 49% in the standard\u2010risk and high\u2010risk groups, respectively. Lower leukemia\u2010free survival was associated with high\u2010risk disease status (<jats:italic>P<\/jats:italic> = .001), chronic myelogenous leukemia disease type (<jats:italic>P<\/jats:italic> = .004), neutrophil engraftment beyond 13 days after transplant (<jats:italic>P<\/jats:italic> = .012), and the occurrence of grades 2 through 4 acute GVHD (<jats:italic>P<\/jats:italic> = .019).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The results from the authors' 9\u2010year experience showed that G\u2010BM combined with peripheral blood stem cells from haploidentical donors, without in vitro TCD, is a reliable source of stem cells for transplantation by using the protocol developed by the authors. Cancer 2013. \u00a9 2012 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.27761","type":"journal-article","created":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T12:38:39Z","timestamp":1350995919000},"page":"978-985","source":"Crossref","is-referenced-by-count":230,"title":["Long\u2010term follow\u2010up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia"],"prefix":"10.1002","volume":"119","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai\u2010Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan\u2010Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91277-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705966"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-1-27"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32831366eb"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705445"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2146"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.117"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.203"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.08.013"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1212"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1572"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.11.025"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890801908903"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.02.007"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-007-9166-z"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1285-1"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.121"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10570"},{"key":"e_1_2_6_21_2","first-page":"246","article-title":"Administration 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