{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:31:46Z","timestamp":1791117106944,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND.<\/jats:title>\n                    <jats:p>Prognostic factors and outcomes in patients with marginal zone lymphoma (MZL) have been studied in small cohort studies, which may not reflect the population at large.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS.<\/jats:title>\n                    <jats:p>Clinical characteristics and survival outcomes of adult patients with MZL who were diagnosed between 1995 and 2009 were evaluated using the Surveillance, Epidemiology, and End Results (SEER) database. The authors generated clinical prognostic models for subtypes of MZL and compared survival during the periods of 1995 through 2000, 2001 through 2004, and 2005 through 2009.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS.<\/jats:title>\n                    <jats:p>\n                      The prognosis was significantly better for patients with mucosa\u2010associated lymphoid tissue (MALT) lymphoma (5\u2010year relative survival rate of 88.7%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001) compared with those with the splenic MZL (SMLZ)or nodal MZL (NMZL) subtypes (5\u2010year relative survival rates of 79.7% and 76.5%, respectively). There was evidence of improved outcomes in patients with NMZL and MALT lymphomas between 1995 and 2009 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001), with no difference noted in patients with SMZL (\n                      <jats:italic>P<\/jats:italic>\n                      = .56). Advancing age and the presence of B symptoms had prognostic significance in all MZL subtypes. Male sex and stage of disease were significant only for the NMZL and MALT categories. Survival in patients with MALT lymphomas varied depending on the site of origin, with a worse prognosis noted in those with gastrointestinal and pulmonary locations of origin (5\u2010year incidence rate of lymphoma\u2010related death, 9.5%\u201014.3%) compared with ocular, cutaneous, and endocrine sites (4.5%\u20107.8%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS.<\/jats:title>\n                    <jats:p>The survival for patients with SMZL is similar to that for those with NMZL, and unlike the NMZL and MALT subtypes, it has not improved over the past decade. The prognosis of patients with MALT lymphoma varies according to the anatomical site of origin. Cancer 2013. \u00a9 2012 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.27773","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T11:48:34Z","timestamp":1344944914000},"page":"629-638","source":"Crossref","is-referenced-by-count":187,"title":["Survival of patients with marginal zone lymphoma"],"prefix":"10.1002","volume":"119","author":[{"given":"Adam J.","family":"Olszewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge J.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,14]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2486"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1226-z"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2008.1.359"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04165.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2002.n.010"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.1950"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07677.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01301.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3496"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1337-6"},{"key":"e_1_2_7_13_2","unstructured":"Surveillance Epidemiology and End Results (SEER) Program.SEER*Stat Database: Incidence\u2010SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases Nov 2011 Sub (1973\u20102009 varying)\u2010Linked To County Attributes\u2010Total US 1969\u20102010 Counties. 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