{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:44:33Z","timestamp":1787240673033,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T00:00:00Z","timestamp":1352160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>No consensus exists on the need to excise breast lesions that yield classic lobular carcinoma in situ (LCIS) or atypical lobular hyperplasia (ALH) (known together as classic lobular neoplasia [LN]) as the highest risk lesion at percutaneous core\u2010needle biopsy (CNB). Here, the authors report findings from 72 consecutive lesions with LN at CNB and prospective surgical excision (EXB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Lesions that yielded LN at CNB at the authors' center have been referred for EXB since June 2004, regardless of imaging\u2010histologic\n                      <jats:italic>concordance<\/jats:italic>\n                      . A lesion was \u201c\n                      <jats:italic>concordant<\/jats:italic>\n                      \u201d if histologic findings provided sufficient explanation for imaging. An upgrade consisted of ductal carcinoma in situ and\/or invasive carcinoma at EXB. Statistical analysis, including 95% confidence intervals (CIs), was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Between June 2004 and May 2009, CNB of 85 consecutive lesions yielded LN without other high\u2010risk histologies. Eighty of 85 lesions (94%) underwent prospective EXB. Seventy\u2010two of 85 lesions (90%; 42 LCIS, 30 ALH) had\n                      <jats:italic>concordant<\/jats:italic>\n                      imaging\u2010histologic findings. EXB yielded low\u2010grade carcinoma in 2 of 72 cases (3%; 95% CI, 0%\u20109%). In both patients, stereotactic, 11\u2010gauge, vacuum\u2010assisted biopsy of calcifications yielded calcifications in benign parenchyma and ALH. CNB results were\n                      <jats:italic>discordant<\/jats:italic>\n                      in 8 of 80 lesions (10%; 4 LCIS, 4 ALH), and EXB yielded cancer in 3 of those 8 lesions (38%; 95% CI, 9%\u201076%). The upgrade rate was significantly higher for\n                      <jats:italic>discordant<\/jats:italic>\n                      lesions versus\n                      <jats:italic>concordant<\/jats:italic>\n                      lesions (38% vs 3%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      Prospective excision of LN identified carcinoma in 3% (95% CI, 0%\u20109%) of\n                      <jats:italic>concordant<\/jats:italic>\n                      cases versus 38% (95% CI, 9%\u201076%) of\n                      <jats:italic>discordant<\/jats:italic>\n                      cases. The current data provide an unbiased assessment of the upgrade rate of LN diagnosed at CNB. Cancer 2013. \u00a9 2012 American Cancer Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.27841","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T16:51:24Z","timestamp":1352220684000},"page":"1073-1079","source":"Crossref","is-referenced-by-count":117,"title":["Classic lobular carcinoma in situ and atypical lobular hyperplasia at percutaneous breast core biopsy"],"prefix":"10.1002","volume":"119","author":[{"given":"Melissa P.","family":"Murray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Luedtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Liberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Nehhozina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzaffar","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edi","family":"Brogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<737::AID-CNCR2820420247>3.0.CO;2-T"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)45184-4"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr624"},{"key":"e_1_2_6_6_2","first-page":"1051","article-title":"Recommendations for women with lobular carcinoma in situ (LCIS)","volume":"25","author":"Oppong BA","year":"2011","journal-title":"Oncology (Williston Park)."},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.173.2.10430122"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.5858\/2002-126-0697-EBSBPI","article-title":"Excisional biopsy should be performed if lobular carcinoma in situ is seen on needle core biopsy","volume":"126","author":"Shin SJ","year":"2002","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000051930.68104.92"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2313040154"},{"key":"e_1_2_6_11_2","volume-title":"Breast Imaging Reporting and Data System: American College of Radiology BI\u2010RADS Imaging Atlas","author":"D'Orsi C","year":"2003"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001215)89:12<2538::AID-CNCR4>3.0.CO;2-#"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2531"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90105-X"},{"key":"e_1_2_6_15_2","series-title":"Geigy Sceintific Tables: Introduction to Statistics, Statistical Tables, Mathematical Formulae","author":"Lenter C","year":"1983"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.171.6.9843311"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.5.1761255"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.218.2.r01fe32503"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.0809"},{"key":"e_1_2_6_20_2","first-page":"52","article-title":"MRI imaging patterns of lesions yielding lobular carcinoma in situ [abstract]","volume":"180","author":"Liberman L","year":"2003","journal-title":"Am J Roentgenol."},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23415"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.134"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000152566.78066.d1"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200012000-00009"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2006.02030.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181b18a89"},{"key":"e_1_2_6_27_2","volume-title":"World Health Organization Classification of Tumors. 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