{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:29:17Z","timestamp":1790630957058,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T00:00:00Z","timestamp":1353888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The objectives of this study were to determine the incidence of locoregional failure in patients with low\u2010risk, early stage oral tongue squamous cell cancer (OTSCC) who undergo partial glossectomy and ipsilateral elective neck dissection without receiving postoperative radiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A combined database of patients with OTSCC who received treatment at Memorial Sloan\u2010Kettering Cancer Center and Princess Margaret Cancer Center from 1985 to 2005 was established. In total, 164 patients with pathologic T1\u2010T2N0 OTSCC who underwent partial glossectomy and ipsilateral elective neck dissection without postoperative radiation were identified. Patient\u2010related, tumor\u2010related, and treatment\u2010related characteristics were recorded. Local recurrence\u2010free survival, regional recurrence\u2010free survival, and disease\u2010specific survival were calculated by the Kaplan\u2010Meier method. Predictors of outcome were analyzed by univariate and multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      At a median follow\u2010up of 66 months (range 1\u2010171 months), the 5\u2010year rates of local recurrence\u2010free survival, regional recurrence\u2010free survival, and disease\u2010specific survival were 89%, 79.9%, and 85.6%, respectively. Regional recurrence was ipsilateral in 61% of patients and contralateral in 39% of patients. The regional recurrence rate was 5.7% for tumors &lt;4 mm and 24% for tumors \u22654 mm. Multivariate analysis indicated that tumor thickness was the only independent predictor of neck failure (regional recurrence\u2010free survival, 94% vs 72% [\n                      <jats:italic>P<\/jats:italic>\n                      = .02] for tumors &lt;4 mm vs \u22654 mm, respectively). Patients who developed recurrence in the neck had a significantly poorer disease\u2010specific survival compared with those who did not (33% vs 97%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Patients with low\u2010risk, pathologic T1\u2010T2N0 OTSCC had a greater than expected rate of neck failure, with contralateral recurrence accounting for close to 40% of recurrences. Failure occurred predominantly in patients who had primary tumors that were \u22654 mm thick. Cancer 2013. \u00a9 2013 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.27872","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T21:12:58Z","timestamp":1353964378000},"page":"1168-1176","source":"Crossref","is-referenced-by-count":221,"title":["Long\u2010term regional control and survival in patients with \u201clow\u2010risk,\u201d early stage oral tongue cancer managed by partial glossectomy and neck dissection without postoperative radiation"],"prefix":"10.1002","volume":"119","author":[{"given":"Ian","family":"Ganly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane L.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal G.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Gullane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,26]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"SEER Cancer Statistics Review, 1975\u20102009 (Vintage 2009 Populations). 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Neck dissection without postoperative radiotherapy in select patients with oral cavity carcinoma and the pN1 neck [poster P002]. Paper presented at: Eighth International Conference of Head and Neck Cancer; July 21\u201025 2012; Toronto Ontario Canada. Available at:http:\/\/ahns.jnabstracts.com\/Detail.aspx?ID=0398. 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