{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:44:51Z","timestamp":1789019091845,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Childhood exposure to iodine\u2010131 from the 1986 nuclear accident in Chernobyl, Ukraine, led to a sharp increase in papillary thyroid carcinoma (PTC) incidence in regions surrounding the reactor. Data concerning the association between genetic mutations in PTCs and individual radiation doses are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Mutational analysis was performed on 62 PTCs diagnosed in a Ukrainian cohort of patients who were &lt; 18 years old in 1986 and received 0.008 to 8.6 Gy of <jats:sup>131<\/jats:sup>I to the thyroid. Associations between mutation types and <jats:sup>131<\/jats:sup>I dose and other characteristics were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p><jats:italic>RET\/PTC<\/jats:italic> (ret proto\u2010oncogene\/papillary thyroid carcinoma) rearrangements were most common (35%), followed by <jats:italic>BRAF<\/jats:italic> (15%) and <jats:italic>RAS<\/jats:italic> (8%) point mutations. Two tumors carrying <jats:italic>PAX8\/PPAR<\/jats:italic>\u03b3 (paired box 8\/peroxisome proliferator\u2010activated receptor gamma) rearrangement were identified. A significant negative association with <jats:sup>131<\/jats:sup>I dose for <jats:italic>BRAF<\/jats:italic> and <jats:italic>RAS<\/jats:italic> point mutations and a significant concave association with <jats:sup>131<\/jats:sup>I dose, with an inflection point at 1.6 Gy and odds ratio of 2.1, based on a linear\u2010quadratic model for <jats:italic>RET\/PTC<\/jats:italic> and <jats:italic>PAX8\/PPAR<\/jats:italic>\u03b3 rearrangements were found. The trends with dose were significantly different between tumors with point mutations and rearrangements. Compared with point mutations, rearrangements were associated with residence in the relatively iodine\u2010deficient Zhytomyr region, younger age at exposure or surgery, and male sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>These results provide the first demonstration of <jats:italic>PAX8\/PPAR<\/jats:italic>\u03b3 rearrangements in post\u2010Chernobyl tumors and show different associations for point mutations and chromosomal rearrangements with <jats:sup>131<\/jats:sup>I dose and other factors. These data support the relationship between chromosomal rearrangements, but not point mutations, and <jats:sup>131<\/jats:sup>I exposure and point to a possible role of iodine deficiency in generation of <jats:italic>RET\/PTC<\/jats:italic> rearrangements in these patients. Cancer 2013. \u00a9 2013 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.27893","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T17:56:54Z","timestamp":1361469414000},"page":"1792-1799","source":"Crossref","is-referenced-by-count":105,"title":["<i>RET\/PTC<\/i> and <i>PAX8\/PPAR<\/i>\u03b3 chromosomal rearrangements in post\u2010Chernobyl thyroid cancer and their association with iodine\u2010131 radiation dose and other characteristics"],"prefix":"10.1002","volume":"119","author":[{"given":"Rebecca J.","family":"Leeman\u2010Neill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina V.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana 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