{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:43:50Z","timestamp":1789940630554,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>More women of fertile age are long\u2010term survivors of cancer. However, population\u2010based data on birth rates of female cancer survivors are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>A total of 42,691 women \u2264 45 years with a history of cancer were identified from the Swedish Multi\u2010Generation Register and the Swedish Cancer Register, for whom relative birth rates were calculated as compared to the background population, ie, standardized birth ratios (SBRs). Independent factors associated with reduced birth rates among cancer survivors were estimated using Poisson modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Compared to the background population, cancer survivors were 27% less likely to give birth (SBR = 0.73, 95% confidence interval [CI] = 0.72\u20100.75). Large difference in SBRs existed by cancer site, with high SBRs for survivors of melanoma skin, thoracic, head and neck, and thyroid cancers, and low SBRs for reproductive, breast, brain and eye, and hematopoietic cancer survivors. Parity status at diagnosis affected fertility: women who already had a child at the time of diagnosis were less likely to give birth (SBR = 0.50, 95% CI = 0.48\u20100.53) than were nulliparous women (SBR = 0.87, 95% CI = 0.85\u20100.90). Multivariate analysis showed that cancer site (reproductive organs), age at onset of cancer (&lt; 12 years), and parity status were all significant and independent predictors of a reduced probability of giving birth after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Cancer survivors are less likely to give birth compared with the background population. Large variations in the likelihood to give birth after diagnosis were seen according to age at onset, cancer site, and parity status at diagnosis. Cancer 2013. \u00a9 2013 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.27929","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T17:54:50Z","timestamp":1361469290000},"page":"1892-1899","source":"Crossref","is-referenced-by-count":48,"title":["Birth rates among female cancer survivors"],"prefix":"10.1002","volume":"119","author":[{"given":"Mikael","family":"Hartman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Czene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Seng","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agus","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M.","family":"Verkooijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"FerlayJ ShinHR BrayF FormanD MathersC ParkinDM. GLOBOCAN 2008 Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon France: International Agency for Research on Cancer; 2010.http:\/\/globocan.iarc.fr. 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Multi\u2010Generation Register 2006: A Description of Contents and Quality. \u00d6rebro Sweden: Statistics Sweden (Statistiska centralbyr\u00e5n) (SCB) 2007.http:\/\/www.scb.se\/statistik\/_publikationer\/BE9999_2006A01_BR_BE96ST0703.pdf. Accessed March 16 2012."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_6_16_2","unstructured":"World Health Organization. International Classification of Diseases Revision 7. Geneva Switzerland: WHO; 1955.http:\/\/www.wolfbane. com\/icd\/icd7.htm. 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