{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:21:37Z","timestamp":1775600497369,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,6,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Population\u2010based studies comprehensively describing incidence patterns of human papillomavirus (HPV)\u2010related preinvasive and invasive neoplasms prior to widespread HPV vaccination are sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Age\u2010adjusted incidence rates (IRs), IR ratios (IRRs), and annual percent changes (APCs) in IRs were calculated for potentially HPV\u2010related tumors diagnosed in the Surveillance, Epidemiology and End Results (SEER) Program during 1978 through 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall IRs for preinvasive tumors were significantly higher than for invasive squamous cell tumors of cervix (IRR\u2009=\u20093.42), vulva (IRR\u2009=\u20091.87), and vagina (IRR\u2009=\u20091.19) and significantly lower for adenomatous cervical tumors (IRR\u2009=\u20090.43), and squamous cell tumors of penis (IRR\u2009=\u20090.64), anus (males, IRR\u2009=\u20090.53; females, IRR\u2009=\u20090.14), and head and neck (H&amp;N) (males, IRR\u2009=\u20090.01; females, IRR\u2009=\u20090.02). Incidence of preinvasive squamous tumors of cervix, vagina, and penis rose rapidly over time and decreased for invasive neoplasms. The most rapid increases occurred for preinvasive (males, APC\u2009=\u200916.0; females, APC\u2009=\u20097.3) and invasive anal tumors (males, APC\u2009=\u20093.6; females, APC\u2009=\u20092.3). IR patterns were generally similar among evaluable racial\/ethnic groups, with the exception of H&amp;N invasive tumor IRs which increased exclusively among white males.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Contrary to the opposing trends of preinvasive and invasive squamous tumors of cervix, vagina, and penis, preinvasive and invasive anal tumor IRs increased significantly over time by sex, age, and racial\/ethnic groups. Successful HPV vaccination programs are needed to measurably reduce incidence of HPV\u2010related neoplasms in the future, particularly for cancer sites with rising incidence rates for which effective screening modalities are limited. Cancer 2013;119:2291\u20132299. \u00a9 2013 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.27989","type":"journal-article","created":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T10:44:45Z","timestamp":1365677085000},"page":"2291-2299","source":"Crossref","is-referenced-by-count":48,"title":["Incidence of potentially human papillomavirus\u2013related neoplasms in the United States, 1978 to 2007"],"prefix":"10.1002","volume":"119","author":[{"given":"George","family":"Kurdgelashvili","sequence":"first","affiliation":[{"name":"Department of Veterans Affairs Medical Center Oklahoma City Oklahoma"},{"name":"University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gra\u00e7a M.","family":"Dores","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center Oklahoma City Oklahoma"},{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Department of Health and Human Services Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer A.","family":"Srour","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center Oklahoma City Oklahoma"},{"name":"University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil K.","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Department of Health and Human Services Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Huycke","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center Oklahoma City Oklahoma"},{"name":"University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan S.","family":"Devesa","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Department of Health and Human Services Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,11]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"US Food and Drug Administration. 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