{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:33:46Z","timestamp":1767861226775,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T00:00:00Z","timestamp":1370822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,7,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The objective of this study was to determine whether age, sex, a positive family history of colorectal cancer, and body mass index (BMI) are important predictors of advanced neoplasia in the setting of screening computed tomographic colonography (CTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Consecutive patients who were referred for first\u2010time screening CTC from 2004 to 2011 at a single medical center were enrolled. Results at pathology were recorded for all patients who underwent polypectomy. Logistic regression was used to identify significant predictor variables for advanced neoplasia (any adenoma \u226510 mm or with villous component, high\u2010grade dysplasia, or adenocarcinoma). Odds ratios (ORs) were used to express associations between the study variables (age, sex, BMI, and a positive family history of colorectal cancer) and advanced neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In total, 7620 patients underwent CTC screening. Of these, 276 patients (3.6%; 95% confidence interval [CI], 3.2%\u20104.1%) ultimately were diagnosed with advanced neoplasia. At multivariate analysis, age (mean OR per 10\u2010year increase, 1.8; 95% CI, 1.6\u20102.0) and being a man (OR, 1.7; 95% CI, 1.3\u20102.2) were independent predictors of advanced neoplasia, whereas BMI and a positive family history of colorectal cancer were not. The number needed to screen to detect 1 case of advanced neoplasia varied from 51 among women aged \u226455 years to 10 among men aged &gt;65 years. The number of post\u2010CTC colonoscopies needed to detect 1 case of advanced neoplasia varied from 2 to 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Age and sex were identified as important independent predictors of advanced neoplasia risk in individuals undergoing screening CTC, whereas BMI and a positive family history of colorectal cancer were not. These results have implications for appropriate patient selection. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013;119:2549\u20132554<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28007","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T09:22:50Z","timestamp":1370856170000},"page":"2549-2554","source":"Crossref","is-referenced-by-count":10,"title":["Computed tomographic colonography for colorectal cancer screening"],"prefix":"10.1002","volume":"119","author":[{"given":"Cesare","family":"Hassan","sequence":"first","affiliation":[{"name":"Digestive Endoscopy Unit Nuovo Regina Margherita Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. Dustin","family":"Pooler","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Humanitas Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Repici","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Humanitas Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry J.","family":"Pickhardt","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24760"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-9-200811040-00245"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60551-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.156448"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800996"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070543"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031618"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101887"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.832"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.09.016"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22668"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4921"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.7671"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.002"},{"key":"e_1_2_7_16_1","first-page":"473","article-title":"Principles and practice of screening for disease","volume":"22","author":"Wilson JMG","year":"1968","journal-title":"WHO Chron"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054967"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.22.2959"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.180"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.182"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181e10daa"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.7842"},{"key":"e_1_2_7_23_1","article-title":"Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer [published online ahead of print November 13, 2012]","author":"Ng SC","year":"2012","journal-title":"Gastroenterology"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2361041926"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2136"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-010-9666-9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2291"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.28007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.28007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:27:26Z","timestamp":1760300846000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.28007"}},"subtitle":["Risk factors for the detection of advanced neoplasia"],"short-title":[],"issued":{"date-parts":[[2013,6,10]]},"references-count":26,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2013,7,15]]}},"alternative-id":["10.1002\/cncr.28007"],"URL":"https:\/\/doi.org\/10.1002\/cncr.28007","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,10]]}}}