{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:10:06Z","timestamp":1792735806142,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>More than 80,000 postmenopausal breast cancer patients in the United States each year are estimated to begin a 5\u2010year course of aromatase inhibitors (AIs) to prevent recurrence. AI\u2010related arthralgia (joint pain and\/or stiffness) may contribute to nonadherence, but longitudinal data are needed on arthralgia risk factors, trajectories, and background in postmenopause. This study sought to describe 1\u2010year arthralgia trajectories and baseline covariates among patients with AI and a postmenopausal comparison group.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients initiating AIs (n\u2009=\u200991) were surveyed at the time of AI initiation and at 6 repeated assessments over 1 year. A comparison group of postmenopausal women without breast cancer (n\u2009=\u2009177) completed concomitantly timed surveys. Numeric rating scales (0\u201310) were used to measure pain in 8 joint pair groups (bilateral fingers, wrists, elbows, shoulders, hips, knees, ankles, and toes). Poisson regression models were used to analyze arthralgia trajectories and risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>By week 6, the AI\u2010initiating group had more severe arthralgia than did the comparison group (ratio of means\u2009=\u20091.8, 95% confidence interval\u2009=\u20091.24\u20102.7, <jats:italic>P<\/jats:italic>\u2009=\u2009.002), adjusting for baseline characteristics. Arthralgia then worsened further over 1 year in the AI group. Menopausal symptom severity and existing joint\u2010related comorbidity at baseline among women initiating AI were associated with more severe arthralgia over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Patients initiating AI should be told about the timing of arthralgia over the first year of therapy, and advised that it does not appear to resolve over the course of a year. Menopausal symptoms and joint\u2010related comorbidity at AI initiation can help identify patients at risk for developing AI\u2010related arthralgia. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013;119:2375\u20132382<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28016","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T12:09:32Z","timestamp":1365595772000},"page":"2375-2382","source":"Crossref","is-referenced-by-count":35,"title":["Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort"],"prefix":"10.1002","volume":"119","author":[{"given":"Liana D.","family":"Castel","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid A.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R.","family":"Saville","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad S.","family":"Boomershine","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana G.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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