{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:27:17Z","timestamp":1761863237594,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,8,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Over the past 2 decades, significant progress has been made in the field of metastatic colorectal cancer (mCRC) regarding new imaging techniques, surgical interventions, and systemic therapy. It is not known whether the benefit from these interventions has extended overall survival (OS) within the general mCRC population. A population\u2010based survival analysis of newly diagnosed patients who presented with mCRC was therefore performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Survival statistics were extracted from the Surveillance, Epidemiology, and End Results (SEER) database for patients diagnosed with mCRC between 1988 and 2008. Demographic variables collected included age, race, and tumor grade. Survival was analyzed using the Kaplan\u2010Meier method and extended Cox proportional hazard model as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The study population consisted of 42,347 patients diagnosed with mCRC between 1988 and 2008 (52% women; mean age, 67 years). The 1\u2010 and 2\u2010year estimated OS rates were 44% and 22%, respectively. Prognostic variables included race, sex, age, tumor location, and year of diagnosis. Median OS improved from 8 months to 14 months between 1988 and 2008. Significant improvements in OS were seen for all disease sites, but especially for descending colon cancers. Whereas the median OS increased by 13 months in patients \u226450 years of age and by 7 months in patients 51\u201070 years of age, the median OS of patients &gt;70 years of age increased by only 1 month between 1988 and 2008.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>There has been a continuous improvement in OS of patients diagnosed with mCRC between 1988 and 2008, especially for left\u2010sided tumors. Little improvement has been seen in patients over 70 years of age. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013;119:3084\u20143091<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28143","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T12:39:15Z","timestamp":1369831155000},"page":"3084-3091","source":"Crossref","is-referenced-by-count":40,"title":["Changing prognosis of metastatic colorectal adenocarcinoma: Differential improvement by age and tumor location"],"prefix":"10.1002","volume":"119","author":[{"given":"Talia","family":"Golan","sequence":"first","affiliation":[{"name":"The Oncology Institute at the Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"The Sackler School of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Urban","sequence":"additional","affiliation":[{"name":"The Oncology Institute at the Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raanan","family":"Berger","sequence":"additional","affiliation":[{"name":"The Oncology Institute at the Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"The Sackler School of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaacov Richard","family":"Lawrence","sequence":"additional","affiliation":[{"name":"The Oncology Institute at the Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Department of Radiation Oncology Jefferson Medical College Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.8397"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033025"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.16.2938"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02034-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.09.046"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431302"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.113"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032691"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1200\/JCO.2005.05.025","article-title":"Hepatic resection: the last surgical frontier for colorectal cancer","volume":"23","author":"Petrelli NJ","year":"2005","journal-title":"J Clin Oncol."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.02.093"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199909000-00004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31815aa2c2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.22.2720"},{"key":"e_1_2_7_16_1","first-page":"1117","article-title":"The Surveillance, Epidemiology, and End Results program: a national resource","volume":"8","author":"Hankey BF","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_7_17_1","unstructured":"National Cancer Institute.Surveillance Epidemiology and End Results. 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