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Elevated corticosteroid sulfate excretion was present in38% of patients with locally recurrent breast cancer and 30% of those with distant metastases, but in only 13% of the \u201cearly\u201d breast cancer cases. A similar abnormality was seen in colonic cancer. Urinary free cortisol was usually normal. ACTH stimulation in a normal subject produced marked increases of both urinary free cortisol and corticosteroid sulfates. It is concluded that elevated corticosteroid sulfate excretion in cancer patients arises from an increased cortisol production rate combined with increased sulfurylation of the steroid. In bronchial carcinoma patients, changes similar to those occurring in the ACTH\u2013treated normal subject may have resulted from ectopic ACTH production in the tumor.<\/jats:p>","DOI":"10.1002\/cncr.2820360921","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T00:27:02Z","timestamp":1278635222000},"page":"2060-2063","source":"Crossref","is-referenced-by-count":12,"title":["The urinary excretion of corticosteroid sulfates by cancer patients"],"prefix":"10.1002","volume":"36","author":[{"given":"D. P.","family":"Rose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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