{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:49:56Z","timestamp":1760316596340,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,8,2]],"date-time":"2010-08-02T00:00:00Z","timestamp":1280707200000},"content-version":"vor","delay-in-days":6728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The leukemic T\u2010celis of the six patients with T\u2010cell chronic lymphocytic leukemia (T\u2010CLL), four with CD4 and CD45R\u2010positive (CD4+ CD45R*) T\u2010CLL and two with CD8 and CD45R\u2010positive (CD8+ CD45R+) T\u2010CLL pheno\u2010type were studied for detailed immunologic phenotypic and functional characteristics. The levels of soluble in\u2010terleukin\u20102 receptors were elevated significantly in the serum of all four patients with CD4+ CD45R+ T\u2010CLL. Moreover, the CD4+ CD45R+ T\u2010CLL patients' T\u2010cells, after <jats:italic>in vitro<\/jats:italic> stimulation with phytohemagglutinin and concanavalin A, expressed elevated percentages of interieukin\u20102 receptors on cells and secreted high interleukin\u20102 activity. The B\u2010cell growth factor (BCGF) activity from three patients with CD4+ CD45R+ T\u2010CLL was enhanced, but B\u2010cell differentiation factor (BCDF) activity of the all T\u2010CLL patients was decreased. Reduced BCGF and BCDF activity of the leukemic T\u2010cells was one possible mechanism of hypogammaglobulinemia detected in two patients with T\u2010CLL. All T\u2010CLL patients' leukemic T\u2010cells had diminished immunoregulatory functional activity in allogeneic mixed lymphocyte reactions. These observations suggest that leukemic T\u2010cells from T\u2010CLL patients have many immunologic functional defects that may be important in their proliferative potential.<\/jats:p>","DOI":"10.1002\/cncr.2820690514","type":"journal-article","created":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T14:49:56Z","timestamp":1281883796000},"page":"1146-1152","source":"Crossref","is-referenced-by-count":4,"title":["T\u2010cell chronic lymphocytic leukemia: T\u2010cell function and lymphokine secretion"],"prefix":"10.1002","volume":"69","author":[{"given":"Syed","family":"Raziuddin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar","family":"Sheikha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulbasit 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