{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:49:40Z","timestamp":1791074980467,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,8,2]],"date-time":"2010-08-02T00:00:00Z","timestamp":1280707200000},"content-version":"vor","delay-in-days":6728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The authors conducted a follow\u2010up study of the association between mediastinal irradiation, chemotherapy, and mortality from coronary artery disease in 4665 patients treated for Hodgkin's disease. Study subjects were followed after the diagnosis of Hodgkin's disease until death or the closing date of the study. The average duration of follow\u2010up was 7 years; 2415 patients died, and 124 cases of coronary artery disease were identified from death certificates, including 68 cases of acute myocardial infarction. The age\u2010adjusted relative risks (RR) of death with any coronary artery disease after mediastinal irradiation and after chemotherapy were 1.87 (95% confidence interval [CI], 0.92 to 3.80) and 1.28 (CI, 0.77 to 2.15), respectively. A significantly increased risk of death in the subcategory myocardial infarction was observed after mediastinal irradiation (RR, 2.56; CI, 1.11 to 5.93) but not after chemotherapy (RR, 0. 97; CI, 0.53 to 1.77). These results support the hypothesis that radiation therapy to the mediastinum increases the risk of coronary artery disease.<\/jats:p>","DOI":"10.1002\/cncr.2820690528","type":"journal-article","created":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T15:29:15Z","timestamp":1281886155000},"page":"1241-1247","source":"Crossref","is-referenced-by-count":232,"title":["Coronary artery disease mortality in patients treated for hodgkin's disease"],"prefix":"10.1002","volume":"69","author":[{"given":"Jean\u2010Fran\u00e7ois","family":"Boivin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George B.","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay H.","family":"Lubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(78)90053-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92283-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820615)49:12<2470::AID-CNCR2820491210>3.0.CO;2-Y"},{"key":"e_1_2_1_5_2","first-page":"977","article-title":"Complications of treatment of Hodgkin's disease in children","volume":"66","author":"Donaldson S","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)38881-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860301)57:5<929::AID-CNCR2820570509>3.0.CO;2-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870815)60:4<772::AID-CNCR2820600411>3.0.CO;2-A"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870701)60:1<31::AID-CNCR2820600107>3.0.CO;2-D"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90029-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(89)80099-6"},{"key":"e_1_2_1_12_2","volume-title":"International Classification of Diseases, Adapted for Use in the United States, vol. 1, revision 8","author":"National Center for Health Statistics","year":"1968"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114759"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-199001000-00001"},{"key":"e_1_2_1_16_2","first-page":"785","volume-title":"Dorland's Illustrated Medical Dictionary","author":"Friel JP","year":"1981"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.79.3.340"},{"key":"e_1_2_1_19_2","first-page":"405","volume-title":"Epidemiological Approaches to the Study of Cancer and Other Chronic Diseases: National Cancer Institute Monograph 19","author":"Moriyama IM","year":"1966"},{"key":"e_1_2_1_20_2","first-page":"84","volume-title":"Modern Epidemiology","author":"Rothman KJ","year":"1986"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.2820690528","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.2820690528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:55:47Z","timestamp":1760288147000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.2820690528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1002\/cncr.2820690528"],"URL":"https:\/\/doi.org\/10.1002\/cncr.2820690528","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}