{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:49:26Z","timestamp":1760316566132,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,8,2]],"date-time":"2010-08-02T00:00:00Z","timestamp":1280707200000},"content-version":"vor","delay-in-days":6728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hodgkin's disease (HD) is uncommon in Taiwan. In reviewing the clinicopathologic features of 50 cases, the authors found that the diagnosis of HD was complicated with non\u2010Hodgkin's lymphoma (NHL). Fourteen cases were reclassified as NHL containing Reed\u2010Sternberg (RS) giant cells, mostly peripheral T\u2010cell lymphoma (PTL), and 34 cases as classic HD, which included 8 cases of lymphocyte predominance, 10 of nodular sclerosis, 12 of mixed cellularity, and 4 of lymphocyte depletion. For cases of HD, there was a bimodal age\u2010incidence distribution with peaks at the third and fifth decades; 61.8% manifested Stage B symptoms and 80.6% had Stage III\/IV disease. The group of patients with NHL, compared with those with classic HD, was found to be older (mean age, 41.4 years <jats:italic>versus<\/jats:italic> 33.1 years; <jats:italic>P &lt;<\/jats:italic> 0.05), to have more extranodal disease (35.7% <jats:italic>versus<\/jats:italic> 8.8%, <jats:italic>P &lt;<\/jats:italic> 0.05), less complete remission rate (25% <jats:italic>versus<\/jats:italic> 67.9%, <jats:italic>P &lt;<\/jats:italic> 0.05), and shorter median survival (29 months <jats:italic>versus<\/jats:italic> 90 months). Most of the NHL patients originally were diagnosed as having atypical or unclassified HD. Thus, the authors conclude that the previous observation of a predominance of mixed cellularity HD in Asian regions may be attributable to the inclusion of PTL, which may mimic HD in histology. Because there is a marked difference in clinical behavior and prognosis, it is important to distinguish between HD and NHL containing RS giant cells in an area with a high incidence of PTL.<\/jats:p>","DOI":"10.1002\/cncr.2820690530","type":"journal-article","created":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T15:28:54Z","timestamp":1281886134000},"page":"1254-1258","source":"Crossref","is-referenced-by-count":4,"title":["Hodgkin's disease and non\u2010hodgkin's lymphoma containing reed\u2010sternberg\u2010like giant cells in Taiwan: A clinicopathologic analysis of 50 cases"],"prefix":"10.1002","volume":"69","author":[{"given":"Ruey\u2010Long","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ih\u2010Jen","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao\u2010Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Chong","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiu\u2010Hwa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Ching","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,2]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1331","volume-title":"Cancer: 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