{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:49:41Z","timestamp":1760316581950,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,8,2]],"date-time":"2010-08-02T00:00:00Z","timestamp":1280707200000},"content-version":"vor","delay-in-days":6728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinicopathologic features of 14 patients with angioimmunoblastic lymphadenopathy (AIL)\u2010related lesions were analyzed. Lymph node biopsy specimens from all the patients showed a diffuse obliteration of lymph node architecture, prominent vascular proliferation, a polymorphous cellular infiltrate, including immuno\u2010blasts, and varying degrees of clear cell proliferation. The patients were eight males and six females, with a median age of 58.5 years. All but one were in an advanced stage at the time of diagnosis. Bone marrow involvement was observed in eight patients. Thirteen patients had a negative serologic reaction for antibody to human T\u2010cell leukemia virus type I (HTLV\u2010I), and one patient was considered to be a HTLV\u2010I carrier. Polyclonal hypergammaglobulinemia was observed in 6 patients, and 6 of the 12 patients showed elevated IgE levels. Immunophenotyping of the involved lymph nodes revealed a preponderance of T\u2010cells in all the patients. Eleven of these patients showed a predominance of CD4<jats:sup>+<\/jats:sup> over CD8<jats:sup>+<\/jats:sup> T\u2010cells, and only one patient showed a predominance of CD8<jats:sup>+<\/jats:sup> over CD4<jats:sup>+<\/jats:sup> T\u2010cells. Two of five patients whose gene analysis was carried out showed clonal rearrangement of the T\u2010cell receptor beta chain gene without rearrangement of the immunoglobulin heavy chain genes. Twelve patients received doxorubicin\u2010containing combination chemo therapy; of these, 7 patients achieved complete response, and the other 5 had partial response. Nine patients are still alive with a median follow\u2010up period of 21 months, and five patients died during the follow\u2010up period. Progression to high\u2010grade T\u2010cell lymphoma with systemic infiltration was ascertained in two of three cases for which autopsy was performed. From our experience, we recommend doxorubicin\u2010containing combination chemotherapy as initial therapy for AIL\u2010related lesions.<\/jats:p>","DOI":"10.1002\/cncr.2820690531","type":"journal-article","created":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T15:09:07Z","timestamp":1281884947000},"page":"1259-1267","source":"Crossref","is-referenced-by-count":23,"title":["Clinicopathologic and therapeutic aspects of angioimmunoblastic lymphadenopathy\u2010related lesions"],"prefix":"10.1002","volume":"69","author":[{"given":"Akimichi","family":"Ohsaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youichi","family":"Amemiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasusada","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90553-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90466-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197501022920101"},{"key":"e_1_2_1_5_2","first-page":"13","article-title":"Atypical lymph node hyperplasia with fatal outcome: A report on the histopathological, immunological and clinical investigations of the cases","volume":"14","author":"Suchi T","year":"1974","journal-title":"Recent Advances in RES Research"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1106350"},{"key":"e_1_2_1_7_2","first-page":"151","article-title":"Angio\u2010immunoblastic lymphadenopathy: Report of ten cases and review of the literature","volume":"189","author":"Cullen MH","year":"1979","journal-title":"Q J Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811201)48:11<2493::AID-CNCR2820481124>3.0.CO;2-T"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830200314"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-4-575"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357908309063292"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830715)52:2<318::AID-CNCR2820520221>3.0.CO;2-G"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197802)41:2<578::AID-CNCR2820410226>3.0.CO;2-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90337-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964581"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000225724"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81246-0_28"},{"key":"e_1_2_1_18_2","first-page":"347","article-title":"Immunoblastic lymphadenopathy (IBL)\u2010like T\u2010cell lymphoma","volume":"9","author":"Shimoyama M","year":"1979","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861115)58:10<2224::AID-CNCR2820581011>3.0.CO;2-3"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.9.995"},{"key":"e_1_2_1_21_2","first-page":"1860","article-title":"Report of the committee on Hodgkin's disease staging classification","volume":"31","author":"Carbone PP","year":"1971","journal-title":"Cancer Res"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/52.1-2.203"},{"key":"e_1_2_1_24_2","first-page":"63","article-title":"Transformed malignant lymphoma from Lennert's lesion is a CD4+ T cell lymphoma: An immunohistochemical study","volume":"52","author":"Ohsaka A","year":"1989","journal-title":"Acta Haematol Jpn"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707282970409"},{"key":"e_1_2_1_27_2","first-page":"755","article-title":"Some problems on the histopathological diagnosis of non\u2010Hodgkin's malignant lymphoma. 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