{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:21:56Z","timestamp":1779110516005,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,8,2]],"date-time":"2010-08-02T00:00:00Z","timestamp":1280707200000},"content-version":"vor","delay-in-days":6728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A retrospective review was done on ail high volume choriocarcinomas and other germ cell tumors of men with serum beta\u2010human chorionic gonadotropin (beta\u2010HCG) levels greater than 50,000 mIU\/ml to determine the incidence and characteristics of hyperthyroidism in this setting. Nineteen patients were identified with high beta\u2010HCG levels, but because 2 did not have thyroid function tests performed, the cases of only 17 patients were evaluable. Of these, 14 (82%) had primary testicular carcinoma and 3 (18%) had extragonadal tumors. Beta\u2010HCG levels on presentation ranged from 80,000 to 3,058,000 mIU\/ml, with a median of 243,500 mIU\/ml. Seven of the 17 evaluable cases (41%) had T<jats:sub>4<\/jats:sub> serum levels higher than 12 \u03bcg\/dl (normal level 4 to 12 \u03bcg\/dl) with a median value of 15.4 \u03bcg\/dl (range, 12.6 to 33.5 \u03bcg\/dl); serum T<jats:sub>4<\/jats:sub> levels correlated with beta\u2010HCG levels (r = 0.84). All seven patients with elevated T<jats:sub>4<\/jats:sub> levels had beta\u2010HCG values greater than 200,000 mIU\/ml, and three of these seven had clinical manifestations that could be attributed to an elevated serum T<jats:sub>4<\/jats:sub>; only one patient required specific antithyroid treatment; and after control of primary disease, all other patients had normalization of thyroid function. The most common manifestations of hyperthyroidism in our series were tachycardia, hypertension, and a systolic flow murmur; none of the patients had thyroid gland enlargement, We conclude that subclinical hyperthyroidism is a relatively common phenomenon in germ cell tumors of men with high levels of beta\u2010HCG and that control of the primary disease results in serum T<jats:sub>4<\/jats:sub> level normalization.<\/jats:p>","DOI":"10.1002\/cncr.2820690535","type":"journal-article","created":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T15:40:47Z","timestamp":1281886847000},"page":"1286-1290","source":"Crossref","is-referenced-by-count":49,"title":["Hyperthyroidism in men with germ cell tumors and high levels of beta\u2010human chorionic gonadotropin"],"prefix":"10.1002","volume":"69","author":[{"given":"Sergio A.","family":"Giralt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Dexeus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Amato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avishay","family":"Sella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Logothetis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-20-1-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)33873-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-30-4-423"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196408132710704"},{"key":"e_1_2_1_6_2","first-page":"41","article-title":"Hyperthyroidie par choriocarcinome metastase une nouvelle observation masculine","volume":"136","author":"Marechaud R","year":"1985","journal-title":"Ann Med Interne"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.132.3.432"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-39-4-653"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-118-4-1558"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90255-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-23-7-658"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90014-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-3-307"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(88)80351-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb02294.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-101-6-1880"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-40-3-482"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408368309165761"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-11-840"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90547-4"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-3-374"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.2820690535","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.2820690535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:56:21Z","timestamp":1760288181000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.2820690535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1002\/cncr.2820690535"],"URL":"https:\/\/doi.org\/10.1002\/cncr.2820690535","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}