{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:07:11Z","timestamp":1770822431221,"version":"3.50.1"},"reference-count":179,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":7913,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[1994,1]]},"DOI":"10.1002\/cncr.2820741326","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T23:49:28Z","timestamp":1258588168000},"page":"381-400","source":"Crossref","is-referenced-by-count":131,"special_numbering":"supplement S1","title":["Prognostic factors in early breast carcinoma"],"prefix":"10.1002","volume":"74","author":[{"given":"Edward G.","family":"Mansour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Ravdin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Dressier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"10.1002\/cncr.2820741326-BIB1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1200\/JCO.1989.7.3.355","article-title":"A long-term follow-up study of survival in Stage I (T1NOMO) and Stage II (T1N1MO) breast carcinoma","volume":"7","author":"Rosen","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H","article-title":"Relation of tumor size, lymph node status and survival in 14,740 breast cancer cases","volume":"63","author":"Carter","year":"1989","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB3","first-page":"69","article-title":"Adjuvant therapy for node-negative breast cancer: an update of NSABP findings","volume":"12","author":"Fisher","year":"1993","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1001\/jama.1991.03460030097037","article-title":"Treatment of early-stage breast cancer","volume":"265","author":"NIH Consensus Conference.","year":"1991","journal-title":"JAMA"},{"key":"10.1002\/cncr.2820741326-BIB5","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/1097-0142(196911)24:5<1071::AID-CNCR2820240533>3.0.CO;2-H","article-title":"Cancer of the breast: size of neoplasm and prognosis","volume":"24","author":"Fisher","year":"1969","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB6","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/1097-0142(197803)41:3<1170::AID-CNCR2820410355>3.0.CO;2-I","article-title":"Patterns of relapse and survival following radical mastectomy: analysis of 716 consecutive patients","volume":"41","author":"Valagussa","year":"1978","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H","article-title":"Relation of tumor size, lymph node status and survival in 24,740 breast cancer cases","volume":"63","author":"Carter","year":"1989","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB8","first-page":"73","article-title":"The natural history of node negative breast cancer: predictors of outcome with 40 year follow-up","volume":"12","author":"Quiet","year":"1993","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB9","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1200\/JCO.1988.6.7.1076","article-title":"Relative worth of estrogen or progesterone receptor and pathologic characteristics of differentiation as indicators of prognosis in node-negative breast and Bowel Project Protocol B-06","volume":"6","author":"Fisher","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF01810737","article-title":"Nuclear characteristics as indicators of prognosis in node-negative breast cancer patients","volume":"14","author":"LeDoussal","year":"1989","journal-title":"Breast Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0002-9610(05)80831-1","article-title":"Comparison of classic and quantitative prognostic factors in hormone receptor-positive and hormone receptor-negative female breast cancer","volume":"165","author":"Aaltomaa","year":"1993","journal-title":"Am J Surg"},{"key":"10.1002\/cncr.2820741326-BIB12","first-page":"34A","article-title":"Tumor necrosis is a histoprognosticator for early recurrence and death in Stage II breast cancer [abstract]","volume":"58","author":"Gilchrist","year":"1988","journal-title":"Lab Inves"},{"key":"10.1002\/cncr.2820741326-BIB13","first-page":"101","article-title":"Pregnancy associated plasma protein a and extensive necrosis: clinically significant predictors of early recurrence in Stage I estrogen receptor-negative breast carcinoma","volume":"53","author":"Kuhajda","year":"1985","journal-title":"Lab Invest"},{"key":"10.1002\/cncr.2820741326-BIB14","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1200\/JCO.1990.8.9.1457","article-title":"Prognostic significance of peritumoral lymphatic and blood vessel invasion in node-negative carcinoma of the breast","volume":"8","author":"Lee","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB15","first-page":"73","article-title":"Prognostic variables in node-negative breast cancer: an all subset analysis","volume":"12","author":"Pritchard","year":"1993","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB16","first-page":"96","article-title":"Risk factors for local recurrence following lumpectomy for breast cancer without radiotherapy","volume":"12","author":"McCready","year":"1993","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB17","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/1097-0142(19851001)56:7<1696::AID-CNCR2820560738>3.0.CO;2-N","article-title":"Significance of estrogen and progesterone receptors, disease-free interval, and site of metastasis on survival of breast cancer patients","volume":"56","author":"Alanko","year":"1985","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB18","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1002\/1097-0142(19881215)62:12<2517::AID-CNCR2820621211>3.0.CO;2-9","article-title":"Prognostic value of estrogen and progesterone receptors in operable breast cancer: results of a univariate and multivariate analysis","volume":"62","author":"Chevalier","year":"1988","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB19","first-page":"2985","article-title":"Progesterone and estrogen receptor status as prognostic variables in breast cancer","volume":"43","author":"Mason","year":"1983","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB20","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1200\/JCO.1988.6.7.1076","article-title":"Relative worth of estrogen or progesterone receptor and pathologic characteristics of differentiation as indicators of prognosis in node-negative breast cancer patients: findings from National Surgical Adjuvant Breast and Bowel Project Protocol B-06","volume":"6","author":"Fisher","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB21","first-page":"19","article-title":"Role of steroid hormones receptors as prognostic factors in primary breast cancer","volume":"1","author":"McGuire","year":"1986","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1002\/cncr.2820741326-BIB22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00000441-198807000-00011","article-title":"Review: steroid receptors, cellular kinetics, and lymph node status as prognostic factors in breast cancer","volume":"296","author":"Benner","year":"1988","journal-title":"Am J Med Sci"},{"key":"10.1002\/cncr.2820741326-BIB23","first-page":"6126","article-title":"Prognostic value of steroid hormone receptors: multivariate analysis of systemically untreated patients with node negative primary breast cancer","volume":"47","author":"Thorpe","year":"1987","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/bjc.1991.249","article-title":"The long term prognostic significance of oestrogen receptor analysis in early carcinoma of the breast","volume":"64","author":"Winstanley","year":"1991","journal-title":"Br J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/307745a0","article-title":"Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells","volume":"307","author":"King","year":"1984","journal-title":"Nature (London)"},{"key":"10.1002\/cncr.2820741326-BIB26","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/1097-0142(19880715)62:2<342::AID-CNCR2820620219>3.0.CO;2-1","article-title":"Immunocytochemical detection of progesterone receptor in breast cancer with monoclonal antibody: relation to biochemical assay, disease-free survival and clinical endocrine response","volume":"62","author":"Pertshuk","year":"1988","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1001\/archsurg.1990.01410130113018","article-title":"Immunocytochemical analysis of estrogen receptors in human breast carcinomas: evaluation of 130 cases and review of the literature regarding concordance with biochemical assay and clinical relevance","volume":"125","author":"Allred","year":"1990","journal-title":"Arch Surg"},{"key":"10.1002\/cncr.2820741326-BIB28","first-page":"39","article-title":"Estrogen receptor immunocytochemical assay in paraffin embedded tissue: a better gold standard?","volume":"1","author":"Battifora","year":"1993","journal-title":"Applied Immunohistochemistry"},{"key":"10.1002\/cncr.2820741326-BIB29","first-page":"40","article-title":"The importance of normal and abnormal oestrogen receptor in breast cancer","volume":"14","author":"McGuire","year":"1992","journal-title":"Cancer Surv"},{"key":"10.1002\/cncr.2820741326-BIB30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0960-0760(92)90214-4","article-title":"Abnormal estrogen receptor in clinical breast cancer","volume":"43","author":"McGuire","year":"1992","journal-title":"J Steroid Biochem Molec Biol"},{"key":"10.1002\/cncr.2820741326-BIB31","first-page":"1052","article-title":"Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods","volume":"49","author":"Kinsel","year":"1989","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB32","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0277-5379(90)90013-J","article-title":"The prognostic value of immunohistochemical estrogen receptor analysis in paraffin-embedded and frozen section vs. that of steroid binding assays","volume":"26","author":"Andersen","year":"1990","journal-title":"Eur J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB33","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/1097-0142(19901015)66:8<1663::AID-CNCR2820660802>3.0.CO;2-C","article-title":"Immunocytochemical estrogen and progestin receptor assay in breast cancer with monoclonal antibodies: histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival","volume":"66","author":"Pertschuk","year":"1990","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB34","first-page":"55","article-title":"DNA flow cytometry in solid tumors: practical aspects and clinical applications","volume":"6","author":"Dressier","year":"1989","journal-title":"Semin Diagn Pathol"},{"key":"10.1002\/cncr.2820741326-BIB35","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/cyto.990140505","article-title":"Consensus review of the clinical utility of DNA cytometry in carcinoma of the breast","volume":"14","author":"Hedley","year":"1993","journal-title":"Cytometry"},{"key":"10.1002\/cncr.2820741326-BIB36","first-page":"4729","article-title":"Association of DNA index and S-phase fraction with prognosis of nodes positive early breast cancer","volume":"47","author":"Hedley","year":"1987","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3109\/07357909209024806","article-title":"Are DNA flow cytometry measurements providing useful information in the management of the node negative breast cancer patient?","volume":"10","author":"Dressier","year":"1993","journal-title":"Cancer Invest"},{"key":"10.1002\/cncr.2820741326-BIB38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/1097-0142(19890215)63:4<631::AID-CNCR2820630405>3.0.CO;2-W","article-title":"Sequential cytopunctures during pre-operative chemotherapy for breast cancer: cytomorphologic changes, initial tumor ploidy and tumor regression","volume":"63","author":"Brifford","year":"1989","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB39","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/1097-0142(19920115)69:2<470::AID-CNCR2820690233>3.0.CO;2-L","article-title":"Sequential cyto-punctures during pre-operative chemotherapy for primary breast carcinoma: II. DNA flow cytometry changes during chemotherapy, tumor regression and short-term follow-up","volume":"69","author":"Spyrotas","year":"1992","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB40","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/jnci\/81.18.1383","article-title":"Correlation of pre-treatment proliferative activity with response to cytotoxic chemotherapy","volume":"81","author":"Remvikos","year":"1989","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB41","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1002\/1097-0142(19900615)65:12<2720::AID-CNCR2820651220>3.0.CO;2-B","article-title":"Response to second line hormone treatment for advanced breast cancer: predictive value of ploidy determination","volume":"65","author":"Seymour","year":"1990","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB42","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/jnci\/81.18.1344","article-title":"DNA flow cytometry in early breast cancer: a step in the right direction","volume":"81","author":"Osborne","year":"1989","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB43","first-page":"213","article-title":"The use of DNA flow cytometry to characterize breast cancer cells affected by pre-surgical (neoadjuvant) chemotherapy","volume":"33","author":"Dressier","year":"1992","journal-title":"Proceed AACR"},{"key":"10.1002\/cncr.2820741326-BIB44","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1002\/1097-0142(19930915)72:6<2033::AID-CNCR2820720640>3.0.CO;2-J","article-title":"DNA content measurement can be obtained using archival material for DNA flow cytometry: a comparison with cytogenetic analysis in 56 pediatric solid tumor","volume":"72","author":"Dressier","year":"1993","journal-title":"Cancer."},{"key":"10.1002\/cncr.2820741326-BIB45","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ijc.2910390307","article-title":"Tissue specific markers in flow cytometry of urological cancers: comparing chromosomal and flow cytometric DNA analysis of bladder tumors","volume":"39","author":"Smeets","year":"1987","journal-title":"Int J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB46","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/ijc.2910420411","article-title":"DNA content and genetic-evaluation of human colorectal adenocarcinoma: a study by flow cytometry and cytogenetic analysis","volume":"42","author":"Remvikos","year":"1988","journal-title":"Int J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB47","first-page":"3257","article-title":"Correlation of model chromosome number of cultured non-small cell lung carcinoma with DNA index of solid tumor tissue","volume":"51","author":"Siegfried","year":"1991","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB48","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/cyto.990080217","article-title":"DNA ploidy and survival in breast patients","volume":"8","author":"Cornelisse","year":"1987","journal-title":"Cytometry"},{"key":"10.1002\/cncr.2820741326-BIB49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/02841869209088897","article-title":"Flow cytometric DNA index and S-phase fraction in breast cancer in relation to other prognostic variables and to clinical outcome","volume":"31","author":"Ferno","year":"1992","journal-title":"Acta Oncol"},{"key":"10.1002\/cncr.2820741326-BIB50","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/1097-0142(19881115)62:10<2183::AID-CNCR2820621019>3.0.CO;2-B","article-title":"Improving the prognostic value of DNA flow cytometry in breast cancer by combining DNA index and S-phase fraction: a proposed classification of DNA histograms in breast cancer","volume":"62","author":"Kallioniemi","year":"1988","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ijc.2910450108","article-title":"Prognostic significance of DNA ploidy in a series of 690 primary breast cancer patients","volume":"45","author":"Beerman","year":"1990","journal-title":"Int J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB52","first-page":"4187","article-title":"Prognostic indicators including DNA histogram type, receptor content and staging related to human breast cancer patient survival","volume":"44","author":"Coulson","year":"1984","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB53","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/1097-0142(19841015)54:8<1586::AID-CNCR2820540820>3.0.CO;2-9","article-title":"Correlation of cell cycle kinetics, hormone receptor, histopathology and nodal status in human breast cancer","volume":"54","author":"Moran","year":"1984","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB54","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1200\/JCO.1990.8.12.2040","article-title":"Node negative breast cancer: prognostic subgroups defined by tumor size and DNA flow cytometry","volume":"8","author":"O'Reiller","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB55","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1001\/archsurg.1990.01410190084013","article-title":"The importance of DNA flow cytometry in node negative breast cancer","volume":"125","author":"Winchester","year":"1990","journal-title":"Arch Surg"},{"key":"10.1002\/cncr.2820741326-BIB56","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1056\/NEJM198903093201003","article-title":"DNA flow cytometry predicts for relapse and survival in node negative breast cancer patients","volume":"320","author":"Clark","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1002\/cncr.2820741326-BIB57","first-page":"167","article-title":"Preliminary analysis the impact of DNA flow cytometry measurements to predict time to recurrence in the intergroups (INT 011) node negative clinical trial: an Eastern Cooperative Oncology Group Study","volume":"11","author":"Dressier","year":"1992","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1002\/cncr.2820741326-BIB58","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/1097-0142(19891101)64:9<1894::AID-CNCR2820640923>3.0.CO;2-K","article-title":"The relationship of flow cytometry to clinical and biologic characteristics in women with node negative breast cancer","volume":"64","author":"Muss","year":"1989","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB59","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1056\/NEJM199004123221505","article-title":"Indicators of prognosis in node negative breast cancer","volume":"322","author":"Sigurdsson","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1002\/cncr.2820741326-BIB60","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/1097-0142(19911001)68:7<1465::AID-CNCR2820680702>3.0.CO;2-I","article-title":"DNA flow cytometric analysis of primary operable breast cancer: relation of ploidy and S-phase fraction to prognosis of patients in NSABP B-04","volume":"68","author":"Fisher","year":"1991","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB61","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/1097-0142(19900515)65:10<2315::AID-CNCR2820651025>3.0.CO;2-3","article-title":"Prognostic significance of flow cytometric DNA analyses in node negative breast patients","volume":"65","author":"Lewis","year":"1990","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB62","unstructured":"Intergroup Trial (0102). SWOG 8897 ECOG 2188 CALGB 8897. Phase III comparison of adjuvant chemotherapy with or without endocrine therapy in high risk, node negative breast cancer patients and a natural history follow-up study in low risk, node negative patients. Activated August, 1989."},{"key":"10.1002\/cncr.2820741326-BIB63","unstructured":"NSABP Protocol B-18. A \ufffd\ufffd\ufffdunified\ufffd\ufffd\ufffd trial to compare short, intensive preoperative systemic adriamycin, cyclophosphamide therapy with similar therapy administered in conventional postoperative fashion: B18.2 a study to evaluate DNA histograms by flow cytometry."},{"key":"10.1002\/cncr.2820741326-BIB64","unstructured":"Eastern Cooperative Oncology Group Laboratory study, EST 4189. Clinical significance and therapeutic impact of DNA flow cytometry measurements of ploidy and S-phase in Stage II breast cancer patients."},{"key":"10.1002\/cncr.2820741326-BIB65","unstructured":"Southwest Oncology Group Laboratory Study, SWOG 8854, Intergroup 0104. Prognostic value of cytometry measurements of breast cancer DNA from postmenopausal patients with involved nodes and receptor positive tumors: a companion protocol to SWOG 8814."},{"key":"10.1002\/cncr.2820741326-BIB66","first-page":"113","article-title":"The prognostic value of flow cytometry (FCM) in Stage I and II breast cancer patients","volume":"12","author":"Hupperets","year":"1993","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB67","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/jnci\/84.14.1109","article-title":"Association of over-expression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients","volume":"84","author":"Isola","year":"1992","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB68","unstructured":"Allred D, Clark G, Tandon A, et al. HER2\/neu oncogene expression identified a group of node-negative breast cancer patients at high risk for recurrence. Presented at the American Society of Clinical Oncology Annual Meeting, Washington, DC, May 20\ufffd\ufffd\ufffd22, 1990."},{"key":"10.1002\/cncr.2820741326-BIB69","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/bjc.1990.312","article-title":"Human breast cancer: identification of populations with a high risk of early relapse in relation to both oestrogen receptor status and c-erb-2 overexpression","volume":"62","author":"May","year":"1990","journal-title":"Br J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB70","unstructured":"Patterson MC. Correlation between c-erb-2 amplification and risk of early relapse in node-negative breast cancer [abstract]. 17th Meeting of the International Society for Oncodevelopmental Biology and Medicine, Theoretical and Clinical Cancer Research, September 1989."},{"key":"10.1002\/cncr.2820741326-BIB71","first-page":"A1858","article-title":"Amplification of Her2\/neu oncogene is associated with early metastasis in human breast cancer [abstract]","volume":"31","author":"Borgen","year":"1990","journal-title":"Proc Annu Meeting Am Assoc Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB72","first-page":"84","article-title":"Prognostic value of Her2\/neu overexpression in node-positive breast cancer: results from two randomized adjuvant Mayo\/North Central Cancer Treatment Group trials","volume":"12","author":"Hartmann","year":"1993","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB73","first-page":"63","article-title":"Expression of the c-erb-3 and c-erb-2 gene products lacks of prognostic value in node-negative breast carcinoma","volume":"12","author":"Gasparini","year":"1993","journal-title":"Proc Am Soc Clin Oncol"},{"issue":"2","key":"10.1002\/cncr.2820741326-BIB74","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/07357909009017572","article-title":"Epidermal growth factor receptors and prognosis in breast cancer","volume":"8","author":"Sainsbury","year":"1990","journal-title":"Cancer Invest"},{"key":"10.1002\/cncr.2820741326-BIB75","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0960-0760(90)90422-H","article-title":"Simulatory and inhibitory growth factors and breast cancer","volume":"37","author":"Dickson","year":"1990","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1002\/cncr.2820741326-BIB76","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/307521a0","article-title":"Close similarity of epidermal growth factor receptor and c-erbB oncogene protein sequences","volume":"307","author":"Downward","year":"1984","journal-title":"Nature"},{"key":"10.1002\/cncr.2820741326-BIB77","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(85)91385-6","article-title":"Epidermal growth factor receptors and oestrogen receptors in human breast cancer","volume":"1","author":"Sainsbury","year":"1985","journal-title":"Lancet"},{"key":"10.1002\/cncr.2820741326-BIB78","first-page":"1398","article-title":"Epidermal growth factor receptor status as predictor of early recurrence and death from breast cancer","volume":"1","author":"Sainsbury","year":"1987","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/cncr.2820741326-BIB79","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/bjc.1991.30","article-title":"Epidermal growth factor receptor (EGFr): results of a 6 year follow-up study in operable breast cancer with emphasis on the node negative subgroup","volume":"63","author":"Nicholson","year":"1991","journal-title":"Br J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB80","first-page":"181","article-title":"Epidermal growth factor receptor and other oncogenes as prognostic markers","volume":"11","author":"Harris","year":"1992","journal-title":"Natl Cancer Inst Monogr"},{"issue":"2","key":"10.1002\/cncr.2820741326-BIB81","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01806288","article-title":"Epidermal growth factor receptors and prognosis in primary breast cancer","volume":"17","author":"Spyratos","year":"1990","journal-title":"Breast Cancer Res Treat"},{"issue":"6","key":"10.1002\/cncr.2820741326-BIB82","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0960-0760(90)90425-K","article-title":"Prognostic value of p53 protein and receptors for epidermal growth factor (EGR-R), insulin-like growth factor-1 (IGF-1-R) and somatostatin (SS-R) in patients with breast and ovarian cancer","volume":"37","author":"Foekens","year":"1990","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1002\/cncr.2820741326-BIB83","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/bjc.1991.130","article-title":"Epidermal growth factors in intracranial and breast tumours: their clinical significance","volume":"63","author":"Bolla","year":"1991","journal-title":"Br J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB84","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF01805978","article-title":"Prognostic value of epidermal growth factor receptor in nodepositive breast cancer","volume":"14","author":"Grimaux","year":"1989","journal-title":"Breast Cancer Res Treat"},{"key":"10.1002\/cncr.2820741326-BIB85","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/S0140-6736(88)90856-2","article-title":"Predictive value of EGF receptor in breast cancer","volume":"2","author":"Costa","year":"1988","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/cncr.2820741326-BIB86","first-page":"177","article-title":"Transforming growth factor alpha in human mammary carcinomas and their metastases","volume":"9","author":"Macias","year":"1989","journal-title":"Anticancer Res"},{"key":"10.1002\/cncr.2820741326-BIB87","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0277-5379(91)90262-C","article-title":"Epidermal growth factor receptor expression as a prognostic indicator in breast cancer","volume":"27","author":"Toi","year":"1991","journal-title":"Eur J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB88","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/0959-8049(92)90454-A","article-title":"Prognostic value of epidermal growth factor receptor in a series of 303 breast cancers","volume":"28A","author":"Bolla","year":"1992","journal-title":"Eur J Cancer"},{"issue":"5","key":"10.1002\/cncr.2820741326-BIB89","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1200\/JCO.1992.10.5.686","article-title":"Human breast cancer: prognostic significance of the c-erbB2 oncoprotein compared with epidermal growth factor receptor, DNA ploidy, and conventional pathologic features","volume":"10","author":"Gasparini","year":"1992","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1002\/cncr.2820741326-BIB90","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/jcp.43.5.385","article-title":"Expression of epidermal growth factor receptor in breast carcinoma","volume":"43","author":"Lewis","year":"1990","journal-title":"J Clin Pathol"},{"key":"10.1002\/cncr.2820741326-BIB91","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0960-0760(90)90428-N","article-title":"Growth factor expression in breast tissue","volume":"37","author":"Coombes","year":"1990","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1002\/cncr.2820741326-BIB92","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0140-6736(89)91202-6","article-title":"Expression of epidermal growth factor receptors associated with lack of response to endocrine therapy in recurrence breast cancer","volume":"1","author":"Nicholson","year":"1989","journal-title":"Lancet"},{"key":"10.1002\/cncr.2820741326-BIB93","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0092-8674(80)90621-2","article-title":"A secreted glycoprotein induced by estrogen in human breast cancer cell lines","volume":"20","author":"Westley","year":"1980","journal-title":"Cell"},{"key":"10.1002\/cncr.2820741326-BIB94","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0006-291X(86)90252-4","article-title":"The 52 kDa estrogen-induced protein secreted by MCF7 cells is a lysosomal acidic protease","volume":"138","author":"Morisset","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/cncr.2820741326-BIB95","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1210\/mend-2-2-186","article-title":"Cloning sequencing of the 52K cathepsin-D complementary DNA of MCF7 breast cancer cells and mapping on chromosome II","volume":"2","author":"Augereau","year":"1988","journal-title":"Mol Endocrinol"},{"key":"10.1002\/cncr.2820741326-BIB96","first-page":"3904","article-title":"Increased secretion, altered processing, and glycosylation of pro-cathepsin-D in human mammary cells","volume":"49","author":"Capony","year":"1989","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB97","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1083\/jcb.104.2.253","article-title":"Phosphorylation, glycosylation, and proteolytic activity of the 52K estrogen induced protein of MCF-7 cells","volume":"104","author":"Capony","year":"1987","journal-title":"J Cell Biol"},{"key":"10.1002\/cncr.2820741326-BIB98","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0022-4731(89)90080-0","article-title":"Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer","volume":"34","author":"Rochefort","year":"1989","journal-title":"J Steroid Biochem"},{"key":"10.1002\/cncr.2820741326-BIB99","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0303-7207(89)90035-X","article-title":"Differential regulation of Cathepsin D by sex steroids in mammary cancer and uterine cells","volume":"66","author":"Touitou","year":"1989","journal-title":"Mol Cell Endocrinol"},{"key":"10.1002\/cncr.2820741326-BIB100","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/nar\/16.5.1903","article-title":"Estrogens and growth factors induce MRNA of the pro cathepsin D secreted by breast cancer cell","volume":"16","author":"Cavailles","year":"1988","journal-title":"Nucl Acid Res"},{"key":"10.1002\/cncr.2820741326-BIB101","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1210\/endo-118-4-1537","article-title":"Autocrine growth stimulation of the MCF 7 breast cancer cells by the estrogen-regulated 52 K protein","volume":"118","author":"Vignon","year":"1986","journal-title":"Endocrinology"},{"key":"10.1002\/cncr.2820741326-BIB102","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1210\/mend-4-9-1327","article-title":"Interactions of cathepsin-D and insulin-like growth factor-II (IGF-II) on the IGF-II\/mannose-6-phosphate receptor in human breast cancer cells and possible consequences on mitogenic activity of IGF-II","volume":"4","author":"Mathieu","year":"1990","journal-title":"Mol Endocrinol"},{"key":"10.1002\/cncr.2820741326-BIB103","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF00049522","article-title":"Cathepsin-D: a protease involved in breast cancer metastasis","volume":"9","author":"Rochefort","year":"1990","journal-title":"Cancer Metastasis Rev"},{"key":"10.1002\/cncr.2820741326-BIB104","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/0014-4827(91)90362-X","article-title":"MCF-7 mammary cancer cells respond to bFGF and internalize it following its release for extracellular matrix: a permissive role of Cathepsin-D","volume":"194","author":"Briozzo","year":"1991","journal-title":"Exp Cell Res"},{"key":"10.1002\/cncr.2820741326-BIB105","first-page":"1809","article-title":"Overexpression of transfected Cathepsin-D in transformed cells increases their malignant phenotype and metastatic potency","volume":"5","author":"Garcia","year":"1990","journal-title":"Oncogene"},{"key":"10.1002\/cncr.2820741326-BIB106","first-page":"3688","article-title":"Invirro degradation of extracellular matrix with Mw 52,000 cathepsin-D secreted by cancer cells","volume":"48","author":"Briozzo","year":"1988","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB107","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/clinchem\/35.1.81","article-title":"Two-site immunoenzymatic assay for the 52 kDa Cathepsin-D in cytosols of breast cancer tissues","volume":"35","author":"Rogler","year":"1989","journal-title":"Clin Chem"},{"key":"10.1002\/cncr.2820741326-BIB108","first-page":"6008","article-title":"Association between high concentration of Mw 52,000 Cathepsin-D and poor prognosis in primary human breast cancer","volume":"49","author":"Thorp","year":"1989","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB109","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0140-6736(89)91487-6","article-title":"Cathepsin-D: an independent prognostic factor for metastasis of breast cancer","volume":"2","author":"Spyratos","year":"1989","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/cncr.2820741326-BIB110","first-page":"439","article-title":"La Cathepsin-D: unfacteur pronostique independant dans le cancer du sein","volume":"75","author":"Romaine","year":"1990","journal-title":"Bull Cancer (Paris)"},{"key":"10.1002\/cncr.2820741326-BIB111","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/clinchem\/37.1.101","article-title":"Cathepsin-D concentration in breast cancer cytosols: correlation with biochemical, histological and clinical findings","volume":"37","author":"Duffy","year":"1991","journal-title":"Clin Chem"},{"key":"10.1002\/cncr.2820741326-BIB112","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF01980938","article-title":"Prognostic value of total Cathepsin-D in breast cancer","volume":"19","author":"Namer","year":"1991","journal-title":"Breast Cancer Res Treat"},{"key":"10.1002\/cncr.2820741326-BIB113","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/0277-5379(91)90260-K","article-title":"Prognostic relevance of Cathepsin-D vs. oestrogen receptors in node-negative breast cancer","volume":"27","author":"Granata","year":"1991","journal-title":"Eur J Cancer"},{"issue":"3","key":"10.1002\/cncr.2820741326-BIB114","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF01833260","article-title":"Urikonase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer","volume":"24","author":"Janicke","year":"1993","journal-title":"Breast Canc Res Treat"},{"issue":"16","key":"10.1002\/cncr.2820741326-BIB115","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1093\/jnci\/84.16.1266","article-title":"Multiparametric prognostic evaluation of biological factors in primary breast cancer","volume":"84","author":"Spyratos","year":"1992","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB116","first-page":"1","article-title":"Cathepsin-D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays","volume":"52","author":"Kute","year":"1992","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB117","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/1097-0142(19930315)71:6<2006::AID-CNCR2820710614>3.0.CO;2-Q","article-title":"Prospective study on the prognostic values of Cathepsin-D levels in breast cancer","volume":"71","author":"Pujol","year":"1993","journal-title":"Cancer."},{"issue":"4","key":"10.1002\/cncr.2820741326-BIB118","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/bjc.1993.139","article-title":"Prognostic significance of Cathepsin-D in patients with breast cancer","volume":"67","author":"Winstanley","year":"1993","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1002\/cncr.2820741326-BIB119","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1200\/JCO.1993.11.1.36","article-title":"Cathepsin-D expression detected by immunohistochemistry has independent prognostic value in axillary node-negative breast cancer","volume":"11","author":"Isola","year":"1993","journal-title":"J Clin Oncol"},{"issue":"9","key":"10.1002\/cncr.2820741326-BIB120","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/1097-0142(19930501)71:9<2756::AID-CNCR2820710912>3.0.CO;2-1","article-title":"Prognostic significance of immunohistochemical analysis of Cathepsin-D in low stage breast cancer","volume":"71","author":"Kandalaft","year":"1993","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB121","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/1097-0142(19900115)65:2<265::AID-CNCR2820650214>3.0.CO;2-1","article-title":"Prognostic significance of the estrogen-regulated protein, Cathepsin-D, in breast cancer: an immunohistochemical study","volume":"65","author":"Henry","year":"1990","journal-title":"Cancer"},{"key":"10.1002\/cncr.2820741326-BIB122","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1056\/NEJM199002013220504","article-title":"Cathepsin-D and prognosis in breast cancer","volume":"322","author":"Tandon","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1002\/cncr.2820741326-BIB123","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jnci\/82.1.4","article-title":"What is the evidence that tumors are angiogenesis dependent?","volume":"82","author":"Folkman","year":"1990","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB124","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0277-5379(91)90189-K","article-title":"Novel growth regulatory factors and tumour angiogenesis","volume":"27","author":"Bicknell","year":"1991","journal-title":"Eur J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jnci\/6.1.73","article-title":"Vascular reactions of normal and malignant tumors in-vivo: I. vascular reactions of mice to wounds and to normal and neoplastic transplants","volume":"6","author":"Alguire","year":"1945","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB126","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00000658-196609000-00012","article-title":"Tumor behavior in isolated perfused organis: in-vitro growth and metastasis of biopsy material in rabbit thyroid and intestinal segment","volume":"164","author":"Folkman","year":"1966","journal-title":"Ann Surg"},{"key":"10.1002\/cncr.2820741326-BIB127","first-page":"419","article-title":"The prognostic significance of tumor vascularity in intermediate thickness (0.76\ufffd\ufffd\ufffd4.0 mm thick) skin melanoma: a quantitative histologic study","volume":"133","author":"Srivasta","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1002\/cncr.2820741326-BIB128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199101033240101","article-title":"Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma","volume":"324","author":"Weidner","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1002\/cncr.2820741326-BIB129","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/339058a0","article-title":"Induction of angiogenesis during the transition from hyperplasia to neoplasia","volume":"339","author":"Folkman","year":"1989","journal-title":"Nature"},{"key":"10.1002\/cncr.2820741326-BIB130","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/00000658-198012000-00012","article-title":"Angiogenic activity as a marker of neoplastic and preneoplastic lesions of the human bladder","volume":"192","author":"Chodak","year":"1980","journal-title":"Ann Surg"},{"key":"10.1002\/cncr.2820741326-BIB131","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0092-8674(91)90642-C","article-title":"Cancer metastases and angiogenesis: an imbalance of positive and negative regulation","volume":"64","author":"Liotta","year":"1991","journal-title":"Cell"},{"key":"10.1002\/cncr.2820741326-BIB132","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0960-0760(92)90364-O","article-title":"Regulation of tumor-host interactions in breast cancer","volume":"41","author":"Dickson","year":"1992","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1002\/cncr.2820741326-BIB133","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/0140-6736(92)93150-L","article-title":"Angiogenesis, assessed by platelet\/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer","volume":"340","author":"Horak","year":"1992","journal-title":"Lancet"},{"key":"10.1002\/cncr.2820741326-BIB134","first-page":"A40","article-title":"Tumor angiogenesis (TA) quantitation by factor VIII-related antigen immunocytochemistry: a new, highly significant, and independent prognostic indicator (PI) in early stage breast carcinoma (ESBC) [abstract]","volume":"11","author":"Gasparini","year":"1992","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB135","first-page":"67","article-title":"Angiogenesis does not predict recurrence in patients with primary breast cancer","volume":"12","author":"Khanuja","year":"1993","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB136","first-page":"1809","article-title":"An antiserum to tumour angiogenesis factor: therapeutic approach to solid tumours","volume":"9","author":"Battiwalla","year":"1989","journal-title":"Anticancer Res"},{"key":"10.1002\/cncr.2820741326-BIB137","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/351453a0","article-title":"The p53 tumour suppressor gene","volume":"351","author":"Levine","year":"1991","journal-title":"Nature"},{"key":"10.1002\/cncr.2820741326-BIB138","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1073\/pnas.88.9.3847","article-title":"Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer","volume":"88","author":"Chen","year":"1991","journal-title":"Proc Natl Acad Sci"},{"key":"10.1002\/cncr.2820741326-BIB139","first-page":"413","article-title":"Loss of chromosome 17[13 sequences and mutation of p53 in human breast carcinomas","volume":"6","author":"Varley","year":"1991","journal-title":"Oncogene"},{"key":"10.1002\/cncr.2820741326-BIB140","doi-asserted-by":"crossref","unstructured":"Vogelstein B, Kinsler KW. p53 function and dysfunction cell. 1992; 70: 523\ufffd\ufffd\ufffd6.","DOI":"10.1016\/0092-8674(92)90421-8"},{"key":"10.1002\/cncr.2820741326-BIB141","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1101\/SQB.1991.056.01.027","article-title":"Regulation of transformation and the cell cycle by p53","volume":"56","author":"Zambetti","year":"1991","journal-title":"Cold Spring Harbor Symposia on Quantitative Biology"},{"key":"10.1002\/cncr.2820741326-BIB142","first-page":"259","article-title":"Relation between p53 overexpression and established prognostic factors in breast cancer","volume":"110","author":"Davidoff","year":"1991","journal-title":"Surgery"},{"key":"10.1002\/cncr.2820741326-BIB143","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/jnci\/84.14.1109","article-title":"Association of over-expression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients","volume":"84","author":"Isola","year":"1992","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB144","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1073\/pnas.89.19.9210","article-title":"Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase","volume":"89","author":"Lin","year":"1992","journal-title":"Proc Natl Acad Sci"},{"key":"10.1002\/cncr.2820741326-BIB145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/358015a0","article-title":"p53 Guardian of the genome","volume":"358","author":"Lane","year":"1992","journal-title":"Nature"},{"key":"10.1002\/cncr.2820741326-BIB146","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jcb.240450108","article-title":"p53 Mutations: gains or losses?","volume":"45","author":"Michalovitz","year":"1991","journal-title":"J Cell Biochem"},{"key":"10.1002\/cncr.2820741326-BIB147","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1349-7006.1991.tb02710.x","article-title":"Nuclear p53 immunoreaction associated with poor prognosis of breast cancer","volume":"82","author":"Iwaya","year":"1991","journal-title":"Jpn J Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB148","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/jnci\/84.11.845","article-title":"Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancer","volume":"84","author":"Thor","year":"1992","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB149","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/jnci\/85.3.200","article-title":"Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer","volume":"85","author":"Allred","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB150","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF01660975","article-title":"Abnormal p53 immunoreactivity and prognosis in node-negative breast carcinomas with long-term follow-up","volume":"421","author":"Bosari","year":"1992","journal-title":"Virchows Arch [A]"},{"key":"10.1002\/cncr.2820741326-BIB151","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0046-8177(93)90158-D","article-title":"Immunohistochemical detection of p53 protein in mammary carcinoma: an important new independent indicator of prognosis","volume":"24","author":"Barnes","year":"1993","journal-title":"Hum Pathol"},{"key":"10.1002\/cncr.2820741326-BIB152","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ijc.2910300404","article-title":"Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer","volume":"30","author":"Crawford","year":"1982","journal-title":"Int J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB153","first-page":"6380","article-title":"The immuno response to p53 in breast cancer patients is directed against the immunodominant epitopes unrelated to the mutational hotspot","volume":"52","author":"Schlichtholz","year":"1992","journal-title":"Cancer Res"},{"key":"10.1002\/cncr.2820741326-BIB154","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0046-8177(93)90157-C","article-title":"The p53 protein expression in mammary ductal carcinoma in situ: relationship to immunohistochemical expression of estrogen receptor and c-erbB-2","volume":"24","author":"Poller","year":"1993","journal-title":"Hum Pathol"},{"key":"10.1002\/cncr.2820741326-BIB155","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0959-8049(05)80431-9","article-title":"Immunochemical analysis of the p53 oncoprotein in matched primary and metastatic human tumours","volume":"29A","author":"Bartkova","year":"1993","journal-title":"Eur J Cancer"},{"key":"10.1002\/cncr.2820741326-BIB156","unstructured":"Grondahl-Hansen J, Thorpe SM, Rosenquist C, Christensen IJ, Rasmussen BB, Pyke C, et al. High levels of u-PA and PAI-1 in cytosols from breast cancer tissue are associated with poor prognosis. 3rd International Workshop on the Molecular and Cellular Biology of Plasminogen Activation, Elsinore, 1991, May 8\ufffd\ufffd\ufffd13."},{"key":"10.1002\/cncr.2820741326-BIB157","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1055\/s-2007-1002624","article-title":"Clinical relevance of the urokinase-type and tissue-type plasminogen activators and of their type 1 inhibitor in breast cancer","volume":"17","author":"Janicke","year":"1991","journal-title":"Semin Thromb Hemost"},{"issue":"1","key":"10.1002\/cncr.2820741326-BIB158","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/oxfordjournals.jbchem.a123014","article-title":"Complete primary structure of the human estrogen-responsive gene (pS2) product","volume":"107","author":"Mori","year":"1990","journal-title":"J Biochem"},{"issue":"1","key":"10.1002\/cncr.2820741326-BIB159","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0014-5793(89)80690-8","article-title":"A new family of growth factor-like peptides \ufffd\ufffd\ufffdTrefoil\ufffd\ufffd\ufffd disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysin)","volume":"250","author":"Thim","year":"1989","journal-title":"FEBS Lett"},{"issue":"3","key":"10.1002\/cncr.2820741326-BIB160","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/j.1460-2075.1989.tb03443.x","article-title":"The 5\ufffd\ufffd\ufffd flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the C-Ha-ras oncoprotein and the c-jun protein","volume":"8","author":"Nunez","year":"1989","journal-title":"EMBO J"},{"issue":"8\ufffd\ufffd\ufffd9","key":"10.1002\/cncr.2820741326-BIB161","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/0959-8049(92)90507-X","article-title":"Prognostic relevance of pS2 status in association with steroid receptor status and proliferative activity in node-negative breast cancer","volume":"28A","author":"Cappelletti","year":"1992","journal-title":"Eur J Cancer"},{"issue":"2","key":"10.1002\/cncr.2820741326-BIB162","first-page":"624","article-title":"pS2 expression and response to hormonal therapy in patients with advanced breast cancer","volume":"51","author":"Schwartz","year":"1991","journal-title":"Cancer Res"},{"issue":"1\ufffd\ufffd\ufffd3","key":"10.1002\/cncr.2820741326-BIB163","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0960-0760(92)90210-A","article-title":"Clinical breast cancer, new developments in selection and endocrine treatment of patients","volume":"43","author":"Klijn","year":"1992","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"13","key":"10.1002\/cncr.2820741326-BIB164","first-page":"3648","article-title":"Response of human breast cancer cells to heat shock and chemotherapeutic drugs","volume":"52","author":"Ciocca","year":"1992","journal-title":"Cancer Res"},{"issue":"3","key":"10.1002\/cncr.2820741326-BIB165","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/jnci\/83.3.170","article-title":"Stress response protein (srp-27) determination in primary human breast carcinomas: clinical, histologic, and prognostic correlations","volume":"83","author":"Thor","year":"1991","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"10.1002\/cncr.2820741326-BIB166","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/jnci\/85.7.570","article-title":"Heat shock protein hsp70 in patients with axillary lymph node negative breast cancer: prognostic implications","volume":"85","author":"Ciocca","year":"1993","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"10.1002\/cncr.2820741326-BIB167","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF01840835","article-title":"Confirmation of a prognostic index for patients with metastatic breast cancer treated by endocrine therapy","volume":"22","author":"Robertson","year":"1992","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"10.1002\/cncr.2820741326-BIB168","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF01840834","article-title":"The Nottingham prognostic index in primary breast cancer","volume":"22","author":"Galea","year":"1992","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"10.1002\/cncr.2820741326-BIB169","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF01840840","article-title":"Proportional hazards and recursive partitioning and amalgamation analyses of the Southwest Oncology Group node-positive adjuvant CMFVP breast cancer data base: a pilot study","volume":"22","author":"Albain","year":"1992","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"10.1002\/cncr.2820741326-BIB170","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01840841","article-title":"A practical application of neural network analysis for predicting outcome of individual breast cancer patients","volume":"22","author":"Ravdin","year":"1992","journal-title":"Breast Cancer Res Treat"},{"key":"10.1002\/cncr.2820741326-BIB171","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0140-6736(92)90997-H","article-title":"Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy","volume":"339","author":"Early Breast Cancer Trialists' Collaborative Group.","year":"1992","journal-title":"Lancet"},{"key":"10.1002\/cncr.2820741326-BIB172","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1200\/JCO.1992.10.5.696","article-title":"Factors predicting treatment responsiveness and prognosis in node-negative breast cancer","volume":"10","author":"Neville","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1002\/cncr.2820741326-BIB173","first-page":"143","article-title":"A model of chemotherapy in node-negative breast cancer","volume":"11","author":"Hillner","year":"1992","journal-title":"Natl Cancer Inst Monogr"},{"key":"10.1002\/cncr.2820741326-BIB174","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc [B]"},{"key":"10.1002\/cncr.2820741326-BIB175","first-page":"63","article-title":"A plain man's guide to the proportional hazards model","volume":"5","author":"Tibshirani","year":"1982","journal-title":"Clin Invest Med"},{"issue":"3","key":"10.1002\/cncr.2820741326-BIB176","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF01806331","article-title":"RECPAM analysis of prognostic factors in patients with Stage III breast cancer","volume":"16","author":"Erlichman","year":"1990","journal-title":"Breast Cancer Res Treat"},{"key":"10.1002\/cncr.2820741326-BIB177","volume-title":"Classification and regression trees.","author":"Breiman","year":"1984"},{"key":"10.1002\/cncr.2820741326-BIB178","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jnci\/83.3.154","article-title":"Breast cancer prognostic factors: evaluation guidelines","volume":"83","author":"McGuire","year":"1991","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/cncr.2820741326-BIB179","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/sim.4780091109","article-title":"Predictive value of statistical models","volume":"9","author":"Van Houwelingen","year":"1990","journal-title":"Stat Med"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.2820741326","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/cncr.2820741326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T09:17:40Z","timestamp":1739438260000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cncr.2820741326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":179,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[1994,1]]}},"URL":"https:\/\/doi.org\/10.1002\/cncr.2820741326","relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}