{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T22:42:12Z","timestamp":1760308932848,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>In the current study, the authors report the results of 39 patients with mantle cell lymphoma (MCL) who were treated with chemotherapy and high\u2010dose rituximab\u2010containing autologous stem cell transplantation (ASCT) during their first disease remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The median age of the patients was 54 years. At the time of diagnosis, 87% of patients had Ann Arbor stage IV disease, and 77% had bone marrow involvement. A Ki\u201067 level of &gt;\u200930% was found in 11 of 27 patients (40%), and SOX11 (SRY [sex determining region Y)\u2010box 11] expression was found to be positive in 17 of 18 patients (94%). Twenty\u2010seven patients (69%) underwent induction therapy with high\u2010dose cytarabine\u2010containing chemotherapy. Rituximab was administered during stem cell collection at a dose of 1000 mg\/m<jats:sup>2<\/jats:sup> on days +1 and +8 after ASCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The estimated 4\u2010year overall survival and progression\u2010free survival rates were 82% and 59%, respectively. Twelve patients experienced disease recurrence. Fifteen of 16 patients who were alive and in complete remission at 36 months remained so at a median follow\u2010up of 69 months (range, 38 months\u2010145 months). The only determinant of recurrence risk found was a Ki\u201067 level of &gt;\u200930%. Seven of 11 patients with a Ki\u201067 level &gt;\u200930% experienced disease recurrence within the first 3 years versus only 3 of 16 patients with a Ki\u201067 level \u2264\u200930% (<jats:italic>P<\/jats:italic>\u2009=\u2009.02). Patients who received high\u2010dose cytarabine did not have a significantly different risk of developing disease recurrence compared with other patients (<jats:italic>P<\/jats:italic>\u2009=\u2009.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Administering ASCT with rituximab during stem cell collection and immediately after transplantation may induce a continuous long\u2010term disease remission in patients with MCL with a Ki\u201067 level of \u2264\u200930%. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013;119:3318\u201325<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28219","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T10:14:10Z","timestamp":1371464050000},"page":"3318-3325","source":"Crossref","is-referenced-by-count":4,"title":["Cytarabine, Ki\u201067, and SOX11 in patients with mantle cell lymphoma receiving rituximab\u2010containing autologous stem cell transplantation during first remission"],"prefix":"10.1002","volume":"119","author":[{"given":"Zaher I.","family":"Chakhachiro","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima M.","family":"Saliba","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace\u2010Julia","family":"Okoroji","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Korbling","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin M.","family":"Alousi","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oran","family":"Betul","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Anderlini","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan O.","family":"Ciurea","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uday","family":"Popat","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Champlin","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry I.","family":"Samuels","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Bueso\u2010Ramos","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issa F.","family":"Khouri","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"229","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1200\/JCO.1997.15.4.1664"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1111\/j.1365-2141.2010.08228.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1182\/blood-2007-06-095331"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1182\/blood-2008-10-184200"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1200\/JCO.2010.33.7055"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1111\/j.1365-2141.2012.09174.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1007\/s12032-011-0136-1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1016\/S1535-6108(03)00028-X"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1002\/cncr.24141"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1158\/0008-5472.CAN-09-3419"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.3324\/haematol.2010.036277"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.3324\/haematol.2009.011759"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1002\/cncr.20923"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1200\/JCO.1999.17.4.1244"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1200\/JCO.2006.09.2403"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1093\/ajcp\/112.4.524"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.1080\/01621459.1958.10501452"},{"doi-asserted-by":"publisher","key":"e_1_2_7_20_1","DOI":"10.1002\/9781118032985"},{"doi-asserted-by":"publisher","key":"e_1_2_7_21_1","DOI":"10.1200\/JCO.2001.19.8.2165"},{"doi-asserted-by":"publisher","key":"e_1_2_7_22_1","DOI":"10.1200\/JCO.2001.19.8.2153"},{"doi-asserted-by":"publisher","key":"e_1_2_7_23_1","DOI":"10.1023\/A:1008389119525"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1182\/blood.V118.21.2005.2005","article-title":"Mature results of BEAM\/high\u2010dose rituximab vs BEAM\/yttrium\u201090 ibritumomab tiuxetan (Zevalin) and autologous stem cell transplantation (ASCT) for relapsed CD20+ follicular and diffuse large b\u2010cell lymphoma: survival outcomes and risk of secondary malignancies [abstract]","volume":"118","author":"Zipp L","year":"2011","journal-title":"Blood"},{"doi-asserted-by":"publisher","key":"e_1_2_7_25_1","DOI":"10.1200\/JCO.2008.19.6121"},{"doi-asserted-by":"publisher","key":"e_1_2_7_26_1","DOI":"10.1182\/blood-2011-12-400580"},{"doi-asserted-by":"publisher","key":"e_1_2_7_27_1","DOI":"10.1093\/annonc\/mdp495"},{"doi-asserted-by":"publisher","key":"e_1_2_7_28_1","DOI":"10.1182\/blood-2011-09-370320"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.28219","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.28219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T22:00:34Z","timestamp":1760306434000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.28219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,17]]},"references-count":27,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/cncr.28219"],"URL":"https:\/\/doi.org\/10.1002\/cncr.28219","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2013,6,17]]}}}