{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:38:43Z","timestamp":1789558723016,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Despite prophylactic platelet transfusions, bleeding remains a significant problem in thrombocytopenic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The antifibrinolytic agent epsilon aminocaproic acid (EACA) was administered to 44 chronically (median duration, 273 days) and severely (platelet count, 8 \u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L; range, 1 \u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L\u2010 19 \u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) thrombocytopenic patients with hematological malignancies. Prophylactic EACA at a dose of 1 g twice daily was orally administered for a median duration of 47 days (range, 7 days\u2010209 days) until the platelet count recovered to\u2009&gt;\u200930; \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L. Platelets were only transfused if bleeding occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>While receiving EACA, 59% of the patients did not bleed, 25% had 19 episodes of spontaneously resolving minor bleeding that did not require platelet transfusion, and 16% received a median of 4 platelet transfusions (range, 1 transfusion\u20108 transfusions) for 1 major traumatic and 9 spontaneous grade 2 to grade 3 bleeding (based on the World Health Organization classification of idiopathic thrombocytopenic purpura). No EACA toxicities were noted, and venous thromboses were not observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>EACA is well tolerated and is associated with a low risk of major bleeding in patients with hematological malignancies who are experiencing chronic severe thrombocytopenia. Cancer 2013;119:3784\u20133787. \u00a9 2013 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.28253","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T19:26:11Z","timestamp":1375817171000},"page":"3784-3787","source":"Crossref","is-referenced-by-count":38,"title":["Epsilon aminocaproic acid prevents bleeding in severely thrombocytopenic patients with hematological malignancies"],"prefix":"10.1002","volume":"119","author":[{"given":"Ana G.","family":"Antun","sequence":"first","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Gleason","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Arellano","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia A.","family":"Langston","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan L.","family":"McLemore","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manila","family":"Gaddh","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuad","family":"el Rassi","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Bernal\u2010Mizrachi","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Galipeau","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Leonard T.","family":"Heffner","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott F.","family":"Winton","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna J.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department  of Hematology and Medical Oncology Winship Cancer Institute of Emory University Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2824.2011.01495.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2008.1.198"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00822.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.5.1519"},{"issue":"5","key":"e_1_2_7_6_1","first-page":"102","article-title":"The platelet\u2010refractory bone marrow transplant patient: prophylaxis and treatment of bleeding","volume":"20","author":"Benson K","year":"1993","journal-title":"Semin 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