{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T22:49:56Z","timestamp":1772059796590,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,10,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>To the best of the authors' knowledge, few population\u2010based studies to date have examined the use of <jats:italic>BRCA1\/2<\/jats:italic> testing or patterns of physician recommendations for genetic testing among women diagnosed with breast cancer. The objective of the current study was to evaluate the rates and predictors of physician recommendation for <jats:italic>BRCA1\/2<\/jats:italic> testing among patients with breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Women aged 18 years to 64 years who were diagnosed with invasive breast cancer in 2007 were identified from the Pennsylvania Cancer Registry and mailed a survey regarding their family history of cancer, physician treatment recommendations, and <jats:italic>BRCA1\/2<\/jats:italic> testing. Of the 4009 women who were sent surveys, 2258 responded (56%). Based on age at diagnosis and family history, women were categorized as being at high, moderate, or low risk of <jats:italic>BRCA1\/2<\/jats:italic> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Nearly 25% of the participants were classified as being at high risk of carrying a <jats:italic>BRCA1\/2<\/jats:italic> mutation based on their age at the time of breast cancer diagnosis and family history of breast and\/or ovarian cancer. Physician recommendations for <jats:italic>BRCA1\/2<\/jats:italic> testing were found to be strongly associated with risk of carrying a mutation, with 53% of high\u2010risk women reporting a testing recommendation compared with 9% of low\u2010risk women. In addition, physician recommendations were strongly correlated with the use of testing in all risk groups. Among high\u2010risk women, the lack of a recommendation for BRCA1\/2 testing was more common among older, low\u2010income, and employed women.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Although <jats:italic>BRCA1\/2<\/jats:italic> testing recommendations appear to be appropriately correlated with mutation risk, a significant percentage of patients with breast cancer who meet criteria for <jats:italic>BRCA1\/2<\/jats:italic> testing may not receive a recommendation for such testing from their health care providers. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013;119:3596\u20133603<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28268","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T11:30:38Z","timestamp":1373974238000},"page":"3596-3603","source":"Crossref","is-referenced-by-count":19,"title":["Are physician recommendations for <i>BRCA1\/2<\/i> testing in patients with breast cancer appropriate? A population\u2010based study"],"prefix":"10.1002","volume":"119","author":[{"given":"Anne Marie","family":"McCarthy","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirar","family":"Bristol","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey","family":"Fredricks","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lache","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Roelfsema","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaijun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy A.","family":"Shea","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Groeneveld","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"},{"name":"Philadelphia Veterans Affairs Medical Center Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Domchek","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"},{"name":"University of Pennsylvania Abramson Cancer Center Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania"},{"name":"University of Pennsylvania Abramson Cancer Center Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.188"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn442"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1237"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.6.1480"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604305"},{"key":"e_1_2_7_7_1","unstructured":"DalyMB AxilbundJE BuysS et al.National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. 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