{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:24:08Z","timestamp":1773289448078,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T00:00:00Z","timestamp":1375228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,10,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>To the best of the authors' knowledge, there has been relatively little research published to date regarding very long\u2010term survivors of childhood and adolescent osteosarcoma. In the current study, the authors compared the very long\u2010term survival outcomes of patients with osteosarcoma who were treated with either limb salvage procedures or amputation.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 38 patients with osteosarcoma who survived \u2265\u200920 years from the time of diagnosis were divided into 2 groups according to whether they underwent amputation or limb salvage. Participants were asked to complete a questionnaire concerning their education, employment, annual income, marital status, health insurance, lifestyle, siblings, and all current and past health issues.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Education, employment, marital status, and health insurance were not found to differ significantly between the 2 groups of survivors, who described themselves as being similar to their siblings. Eight percent of survivors underwent secondary amputation because of complications with an endoprosthesis. The cumulative incidence of second primary neoplasms was 13%, and this finding was significantly higher in females and in survivors who underwent radiotherapy and had a genetic predisposition. The second primary malignancies were breast cancer (ductal invasive carcinoma, ductal in situ carcinoma, and leiomyosarcoma), mediastinal leiomyosarcoma, and squamocellular carcinoma of the oral cavity and the uterine cervix. Amputees required more assistive walking support than survivors who received limb salvage treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05, chi\u2010square test).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Despite the many challenges that osteosarcoma survivors face, patients who survived \u2265\u200920 years after their initial diagnosis reported having overall adjusted well to their physical limitations and were productive individuals. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013;119:3727\u20133736<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28277","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T11:53:36Z","timestamp":1375271616000},"page":"3727-3736","source":"Crossref","is-referenced-by-count":52,"title":["Sociooccupational and physical outcomes more than 20 years after the diagnosis of osteosarcoma in children and adolescents"],"prefix":"10.1002","volume":"119","author":[{"given":"Giulia","family":"Ottaviani","sequence":"first","affiliation":[{"name":"Division of Pediatrics Children's Cancer Hospital The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Clinical Sciences and Community Health University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda S.","family":"Robert","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Children's Cancer Hospital The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winston W.","family":"Huh","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Children's Cancer Hospital The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shana","family":"Palla","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Children's Cancer Hospital The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,31]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"3","volume-title":"Cancer Treat Res","author":"Ottaviani G","year":"2009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22349"},{"key":"e_1_2_7_4_1","first-page":"421","volume-title":"Cancer Treat Res","author":"Ottaviani G","year":"2009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22419"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-287"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa060185"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B6.19805"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25446"},{"key":"e_1_2_7_10_1","unstructured":"OttavianiG RobertRS HuhWW PallaS JaffeN.Late Events in Osteosarcoma Survivors: What Can We Learn From Clinical Trials in Amputation Versus Limb Salvage?Presented at Proceedings of the 34th Meeting of the Scandinavian Sarcoma Group 30 Years' Jubilee; May 6\u20138 2009; Oslo Norway: 33.http:\/\/air.unimi.it\/bitstream\/2434\/54695\/1\/Oslo_09.pdf. 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