{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T23:04:02Z","timestamp":1783811042877,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T00:00:00Z","timestamp":1378771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,11,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The management of pediatric melanoma (PM) has largely been extrapolated from adult data. However, the behavior of PM appears to differ from its adult counterparts. Therefore, an international PM registry was created and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twelve institutions contributed deidentified clinicopathologic and outcome data for patients diagnosed with PM from 1953 through 2008.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall survival (OS) data were reported for 365 patients with invasive PM who had adequate follow\u2010up data. The mean age of the patients was 16 years (range 1 year\u201021 years). The 10\u2010year OS rate, 80.6%, tended to vary by patient age: 100% for those aged birth to 10 years, 69.7% for those aged &gt;\u200910 years to 15 years, and 79.5% for those aged &gt;\u200915 years to 20 years (<jats:italic>P<\/jats:italic>\u2009=\u2009.147). Patients with melanomas measuring \u2264\u20091 mm had a favorable prognosis (10\u2010year OS rate of 97%), whereas survival was lower but similar for patients with melanomas measuring &gt;\u20091 mm to 2 mm, &gt;\u20092 mm to 4 mm, and &gt;\u20094 mm (70%, 78%, and 80%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u2009.0077). Ulceration and lymph node metastasis were found to be correlated with worse survival (<jats:italic>P<\/jats:italic>\u2009=\u2009.022 and <jats:italic>P<\/jats:italic>\u2009=\u2009.017, respectively). The 10\u2010year OS rate was 94.1% for patients with American Joint Committee on Cancer stage I disease, 79.6% for those with stage II disease, and 77.1% for patients with stage III disease (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Tumor thickness, ulceration, lymph node status, and stage were found to be significant predictors of survival in patients with PM, similar to adult melanoma. There is a trend toward increased survival in children aged \u2264\u200910 years versus adolescents aged &gt;\u200910 years. Further analyses are needed to probe for potential biological and behavioral differences in pediatric versus adult melanoma. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013<\/jats:bold>;119:4012\u20134019. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28289","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T03:44:04Z","timestamp":1378871044000},"page":"4012-4019","source":"Crossref","is-referenced-by-count":79,"title":["Pediatric melanoma: Analysis of an international registry"],"prefix":"10.1002","volume":"119","author":[{"given":"Bruce J.","family":"Averbook","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology MetroHealth Medical Center Cleveland Ohio"},{"name":"Department of Surgery Case Western Reserve University Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Delman","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Gow","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Zager","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology H. Lee Moffitt Cancer Center Tampa Florida"},{"name":"Department of Oncologic Sciences University of South Florida Morsani College of Medicine Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon K.","family":"Sondak","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology H. Lee Moffitt Cancer Center Tampa Florida"},{"name":"Department of Oncologic Sciences University of South Florida Morsani College of Medicine Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane L.","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cell Biology and Dermatology University of South Florida Morsani College of Medicine Tampa Florida"},{"name":"Department of Dermatology and Pathology, H. Lee Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Sabel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology University of Michigan Medical Center Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Pittelkow","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip M.","family":"Ecker","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetomir N.","family":"Markovic","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Mayo Clinic Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Swetter","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stanford University Medical Center and VA Palo Alto Health Care System, Pigmented Cell and Melanoma Program, Stanford Cancer Institute Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sancy A.","family":"Leachman","sequence":"additional","affiliation":[{"name":"Melanoma and Cutaneous Oncology Program, Department of Dermatology Huntsman Cancer Institute, Intermountain Healthcare Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Testori","sequence":"additional","affiliation":[{"name":"Melanoma and Soft Tissue Sarcoma Division European Institute of Oncology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Curiel\u2010Lewandrowski","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Department of Medicine, Pigmented Lesion Clinic and Multidisciplinary Cutaneous Oncology Program, University of Arizona Cancer Center Skin Cancer Institute Tucson Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"S. Go","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Gundersen Health System La Crosse Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drazen M.","family":"Jukic","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology Dermatopathology Fellowship Program, University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Kirkwood","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology &amp; Translational Science, University of Pittsburgh School of Medicine Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute Pittsburgh 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