{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:07:07Z","timestamp":1791662827452,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T00:00:00Z","timestamp":1379289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Few studies have examined the acute effects of autologous hematopoietic stem cell transplantation (Au\u2010HSCT) on the neuropsychological functioning of patients with multiple myeloma (MM). The prevalence of cognitive deficits after induction chemotherapy (pre\u2010AuHSCT) was examined in patients with MM, clinically significant changes in cognitive function 1 and 3 months post\u2010AuHSCT were determined, and patients who may be vulnerable to cognitive decline during this period were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 53 patients with MM were recruited pre\u2010AuHSCT. Neuropsychological tests measuring multiple cognitive domains (attention, psychomotor speed, learning\/memory, language, executive function, motor function) were administered pre\u2010AuHSCT and 1 and 3 months post\u2010AuHSCT. A pretreatment assessment was not available. An Overall Cognitive Function Index was computed to determine cognitive impairment pre\u2010AuHSCT, and a practice\u2010effect\u2013adjusted Reliable Change Index was used to determine cognitive change over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall, deficits were more frequent in learning\/memory, executive function, motor function, and psychomotor speed. Before AuHSCT, 47% of patients (25\/53) exhibited cognitive impairment as determined by the Overall Cognitive Function Index. One month post\u2010AuHSCT, 49% of patients (20\/41) demonstrated clinically significant decline on 1 or more measures; 3 months post\u2010AuHSCT, 48% (14 of 29 patients) showed decline on 1 or more measures. Older patients, minorities, and those with advanced disease, more induction cycles, or postinduction deficits showed greater vulnerability to decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Nearly half of the patients showed vulnerability to impairment in learning\/memory or executive function after receiving induction therapy, and the prevalence of impairment remained high post\u2010AuHSCT. Awareness of cognitive impairment and associated risk factors in actively treated patients is important for considering psychosocial or other support for patients with acute cognitive symptoms. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013<\/jats:bold>;119:4188\u20134195. \u00a9<jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28323","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T12:29:00Z","timestamp":1381235340000},"page":"4188-4195","source":"Crossref","is-referenced-by-count":70,"title":["Acute cognitive impairment in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplant"],"prefix":"10.1002","volume":"119","author":[{"given":"Desiree","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth G.","family":"Vichaya","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Shelley","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary H.","family":"Sailors","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Cleeland","sequence":"additional","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Wefel","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-104984"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116129"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200322"},{"key":"e_1_2_7_5_1","first-page":"181","article-title":"Chemoradiotherapy toxicity during bone marrow transplantation: time course and variation in pain and nausea","volume":"4","author":"Chapko MK","year":"1989","journal-title":"Bone Marrow Transplant."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.5.1457"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.9119"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1155"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921101)70:9<2288::AID-CNCR2820700913>3.0.CO;2-M"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10627"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1710"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2009.01145.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acp060"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22962"},{"key":"e_1_2_7_15_1","volume-title":"Beck Depression Inventory II Manual","author":"Beck AT","year":"1996"},{"key":"e_1_2_7_16_1","unstructured":"ShahN JonesD MendozaTR et al.Validation of the M. 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