{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:55:52Z","timestamp":1789181752656,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The incidence and spectrum of acute toxicities related to the use of bevacizumab (BVZ)\u2010containing regimens in children are largely unknown. This report describes the adverse events in a recently completed large phase 2 trial of BVZ plus irinotecan (CPT\u201011) in children with recurrent central nervous system tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Pediatric Brain Tumor Consortium trial\u2010022 evaluated the efficacy and toxicity of BVZ (10 mg\/kg administered intravenously) as a single agent for 2 doses given 2 weeks apart and then combined with CPT\u201011 every 2 weeks (1 course\u2009=\u20094 weeks) in children with recurrent central nervous system tumors. Children were treated until they experienced progressive disease, unacceptable toxicity or completed up to a maximum of 2 years of therapy. Toxicities were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0. Patients who received at least 1 dose of BVZ were included for toxicity assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Between October 2006 and June 2010, 92 patients evaluable for toxicity were enrolled and received 687 treatment courses. The most common toxicities attributable to BVZ included grade I\u2010III hypertension (38% of patients), grade I\u2010III fatigue (30%), grade I\u2010II epistaxis (24%), and grade I\u2010IV proteinuria (22%). Twenty\u2010two patients (24%) stopped therapy due to toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The combination of BVZ and CPT\u201011 was fairly well\u2010tolerated, and most severe BVZ\u2010related toxicities were rare, self\u2010limiting, and manageable. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013<\/jats:bold>;119:4180\u20134187. \u00a9<jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28343","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T11:23:22Z","timestamp":1381231402000},"page":"4180-4187","source":"Crossref","is-referenced-by-count":38,"title":["Bevacizumab (BVZ)\u2010associated toxicities in children with recurrent central nervous system tumors treated with BVZ and irinotecan (CPT\u201011)"],"prefix":"10.1002","volume":"119","author":[{"given":"Jason","family":"Fangusaro","sequence":"first","affiliation":[{"name":"Ann &amp; Robert H. 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