{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:50:46Z","timestamp":1776729046810,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T00:00:00Z","timestamp":1379289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,11,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Patients with cancer are at increased risk of developing complications of influenza. In this study, the authors assessed the effectiveness of influenza vaccination among cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A prospective, noninterventional cohort study was conducted during the 2010 to 2011 influenza season. The cohort included adult cancer patients with solid malignancies who were receiving chemotherapy and hematologic patients who had active disease. Patients who died between October and November 2010 (N\u2009=\u200943) were excluded. A comparison was made between patients who received the 2011 seasonal influenza vaccine with those who did not. The primary outcome was a composite of hospitalizations for fever or acute respiratory infections, pneumonia, and\/or infection\u2010related chemotherapy interruptions. All\u2010cause mortality was a secondary outcome. A propensity\u2010matched analysis was conducted based on the propensity for vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 806 patients who were included, 387 (48%) were vaccinated. Factors that were associated independently with vaccination included past influenza vaccination, past pneumococcal vaccination, &gt;6 months since cancer diagnosis, country of birth, and cancer type\/status. The primary outcome occurred in 111 of 387 (28.7%) vaccinated patients versus 112 of 419 (26.7%) unvaccinated patients (<jats:italic>P<\/jats:italic>\u2009=\u2009.54). No association was observed between vaccination and the primary outcome in a propensity\u2010matched analysis (N\u2009=\u2009436) or during peak influenza activity. The mortality rate was 11.9% (46 of 387 patients) in vaccinated patients versus 19.1% (80 of 419 patients) in unvaccinated patients (<jats:italic>P<\/jats:italic>\u2009=\u2009.005). Vaccination retained a significant association with mortality on multivariable analysis (odds ratio, 2.31; 95% confidence interval, 1.4\u20103.79) and in a propensity\u2010matched analysis (odds ratio, 2.39; 95% confidence interval, 1.32\u20104.32).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Influenza vaccination was associated with lower mortality among cancer patients, although an association with infection\u2010related complications could not be demonstrated. The current results support efforts to promote influenza vaccination in patients with cancer. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013<\/jats:bold>;119:4028\u20134035. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28351","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T11:07:29Z","timestamp":1381230449000},"page":"4028-4035","source":"Crossref","is-referenced-by-count":37,"title":["Clinical effectiveness of seasonal influenza vaccine among adult cancer patients"],"prefix":"10.1002","volume":"119","author":[{"given":"Inbal","family":"Vinograd","sequence":"first","affiliation":[{"name":"Pharmacy Services Schneider Children's Medical Center Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa","family":"Eliakim\u2010Raz","sequence":"additional","affiliation":[{"name":"Department of Medicine E, Rabin Medical Center Beilinson Hospital Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Farbman","sequence":"additional","affiliation":[{"name":"Department of Medicine E, Rabin Medical Center Beilinson Hospital Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Baslo","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Hematology Schneider Children's Medical Center Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Taha","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Sakhnini","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Lador","sequence":"additional","affiliation":[{"name":"Department of Medicine E, Rabin Medical Center Beilinson Hospital Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salomon M.","family":"Stemmer","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Institute of Oncology Davidoff Center, Rabin Medical Center Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Gafter\u2010Gvili","sequence":"additional","affiliation":[{"name":"Department of Medicine E, Rabin Medical Center Beilinson Hospital Petah Tikva Israel"},{"name":"Institute of Oncology Davidoff Center, Rabin Medical Center Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Leibovici","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Department of Medicine E, Rabin Medical Center Beilinson Hospital Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mical","family":"Paul","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Unit of Infectious Diseases, Rabin Medical Center Beilinson Hospital Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Fact sheet no. 211","author":"World Health Organization. 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Summary report\u2014influenza season 2010\u20102011. Israeli Ministry of Health website. Available at:http:\/\/www.old.health.gov.il\/Download\/pages\/summery_flu2010_2011.pdf. Accessed April 1 2013."},{"key":"e_1_2_7_13_1","first-page":"1","article-title":"Influenza surveillance\u2014United States, 1992\u201093 and 1993\u201094","volume":"46","author":"Brammer L","year":"1997","journal-title":"MMWR CDC Surveill Summ"},{"key":"e_1_2_7_14_1","unstructured":"Israel Central Bureau of Statistics.Table 1\u2014Local councils and municipalities: rank cluster membership population variable values standardized values and ranking for the variables used in the computation of the index. Central Bureau of Statistics website. Available at:http:\/\/www.cbs.gov.il\/publications\/local_authorities01\/pdf\/t01.pdf. 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In: Merck Manual Professional Edition [online edition]. Available at:http:\/\/www.merckmanuals.com\/professional\/pulmonary_disorders\/tumors_ of_the_lungs\/lung_carcinoma.html?qt=&sc=&alt=. 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