{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:06:16Z","timestamp":1792166776378,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>An association between the survival of patients with oral cavity squamous cell carcinoma (OCSCC) and advancements in diagnosis and therapy has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This was a retrospective, longitudinal, international, population\u2010based study of 2738 patients who underwent resection of OCSCC during 2 different decades. Characteristics of patients from 7 international cancer centers who received treatment between 1990 and 2000 (group A; n\u2009=\u2009735) were compared with patients who received treatment between 2001 and 2011 (group B; n\u2009=\u20092003).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Patients in group B had more advanced tumors and tended to develop distant metastases more frequently than patients in group A (<jats:italic>P<\/jats:italic>\u2009=\u2009.005). More group B patients underwent selective neck dissection and received adjuvant radiotherapy (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Outcome analysis revealed a significant improvement in 5\u2010year overall survival, from 59% for group A to 70% for group B (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). There was also a significant improvement in disease\u2010specific survival associated with operations performed before and after 2000 (from 69% to 81%, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Surgery after 2000, negative margins, adjuvant treatment, and early stage disease were independent predictors of a better outcome in multivariate analysis. The decade of treatment was an independent prognostic factor for cancer\u2010specific mortality (hazard ratio, 0.42; 95% confidence interval, 0.3\u20100.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The survival rate of patients with OCSCC improved significantly during the past 2 decades despite older age, more advanced disease stage, and a higher rate of distant metastases. The current results suggest that the prognosis for patients with OCSCC has improved over time, presumably because of advances in imaging and therapy. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013;119:4242\u20134248<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28357","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:03:12Z","timestamp":1381525392000},"page":"4242-4248","source":"Crossref","is-referenced-by-count":150,"title":["Improvement in survival of patients with oral cavity squamous cell carcinoma: An international collaborative study"],"prefix":"10.1002","volume":"119","author":[{"given":"Moran","family":"Amit","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Rambam Medical Center and Faculty of Medicine, the Technion Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chen","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Ta","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Department of Surgery Tata Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai Prakash","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Surgery Tata Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz P.","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery and Otorhinolaryngology Department Hospital AC Camargo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardalan","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Clark","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute Royal Prince Alfred Hospital Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kreppel","sequence":"additional","affiliation":[{"name":"Department of Oral and Cranio\u2010Maxillo and Facial Plastic Surgery University of Cologne Cologne 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