{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:44:25Z","timestamp":1773467065636,"version":"3.50.1"},"reference-count":71,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The extent of initial surgical resection has been identified as the strongest prognostic indicator for survival in child and adolescent meningioma. Given the paucity of data concerning long\u2010term outcome, the authors undertook a meta\u2010analysis to analyze morbidity in survivors of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Individual patient data were obtained from 19 case series published over the last 23 years through direct communication with the authors. Ordinal logistic regression models were used to assess the influence of risk factors on morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 261 patients, 48% reported a completely normal life with no morbidity, and 25% had moderate\/severe meningioma\u2010associated morbidity at last follow\u2010up. Multivariate analysis identified relapse as the only independent variable associated with an increased risk of morbidity (odds ratio, 4.02; 95% confidence interval, 2.11\u20107.65; <jats:italic>P<\/jats:italic>\u2009\u2264\u2009.001). Univariate analysis also revealed an increased risk for patients with neurofibromatosis (odds ratio, 1.90; 95% confidence interval, 1.04\u20103.48; <jats:italic>P<\/jats:italic>\u2009=\u2009.04). Subgroup analysis identified a higher incidence of morbidity among patients who had intracranial tumors with a skull base location compared with a nonskull base location (<jats:italic>P<\/jats:italic>\u2009\u2264\u2009.001). Timing at which morbidity occurred was available for 70 patients, with persistence of preoperative tumor\u2010related symptoms in 67% and as a result of therapy in 20%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The majority of survivors of child and adolescent meningioma had no or only mild long\u2010term morbidity, whereas 25% had moderate\/severe morbidity, with a significantly increased risk in patients with relapsed disease. In the majority, morbidity occurred as a consequence of the tumor itself, justifying aggressive surgery to achieve gross total resection. However, for patients with neurofibromatosis and skull base meningioma, a more cautious surgical approach should be reserved. <jats:bold><jats:italic>Cancer<\/jats:italic> 2013;119:4350\u20134357<\/jats:bold>. \u00a9 2013 The Authors. <jats:italic>Cancer<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of the American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28366","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T22:25:39Z","timestamp":1379629539000},"page":"4350-4357","source":"Crossref","is-referenced-by-count":21,"title":["Morbidity in survivors of child and adolescent meningioma"],"prefix":"10.1002","volume":"119","author":[{"given":"Rishi S.","family":"Kotecha","sequence":"first","affiliation":[{"name":"Department of Haematology and Oncology Princess Margaret Hospital for Children Perth Western Australia Australia"},{"name":"School of Paediatrics and Child Health University of Western Australia Perth Western Australia Australia"},{"name":"Telethon Institute for Child Health Research and Centre for Child Health Research University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Jacoby","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research and Centre for Child Health Research University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine H.","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Princess Margaret Hospital for Children Perth Western Australia Australia"},{"name":"School of Paediatrics and Child Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas G.","family":"Gottardo","sequence":"additional","affiliation":[{"name":"Department of 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