{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:05:18Z","timestamp":1777500318195,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["P01 CA049639"],"award-info":[{"award-number":["P01 CA049639"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Chronic myeloid leukemia (CML) may progress to blast phase (BP) at the rate of 1% to 1.5% per year. With the use of single\u2010agent tyrosine kinase inhibitors, median overall survival ranges between 7 and 11 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The outcome was analyzed for 42 patients with lymphoid BP\u2010CML who were treated with hyperfractionated cyclophosphamide, vincristine, Adriamycin, dexamethasone (HCVAD) plus imatinib or dasatinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Complete hematological response was achieved in 90% of patients, complete cytogenetic remission in 58%, and complete molecular remission in 25%. Flow cytometry minimal residual disease negativity was achieved by 42% of evaluable patients after induction. Eighteen patients received allogeneic stem cell transplant (SCT) while in first complete hematological response. Median remission duration was 14 months and was longer among SCT recipients (<jats:italic>P<\/jats:italic>\u2009=\u2009.01) on multivariate analysis. Median overall survival was 17 months (range, 7\u201027 months) and was longer among SCT recipients (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and patients treated with dasatinib (<jats:italic>P<\/jats:italic>\u2009=\u2009.07) on multivariate analysis. Although a high rate of hematologic toxicity (100%) and infectious complications (59%) were observed, the related rate of treatment discontinuation was low (7% and 9%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>HCVAD combined with tyrosine kinase inhibitors is an effective regimen for the management of BP\u2010CML, particularly when followed by allogeneic SCT. <jats:bold><jats:italic>Cancer<\/jats:italic> 2014;120:373\u2013380<\/jats:bold> \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28433","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T15:54:11Z","timestamp":1382457251000},"page":"373-380","source":"Crossref","is-referenced-by-count":62,"title":["HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid 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