{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:54:41Z","timestamp":1792684481690,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000457"],"award-info":[{"award-number":["UL1TR000457"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1RR024996"],"award-info":[{"award-number":["UL1RR024996"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIDCD T32 000027"],"award-info":[{"award-number":["NIDCD T32 000027"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Although obesity increases risk and negatively affects survival for many malignancies, the prognostic implications in squamous cell carcinoma (SCC) of the oral tongue, a disease often associated with prediagnosis weight loss, are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients with T1\u2010T2 oral tongue SCC underwent curative\u2010intent resection in this single\u2010institution study. All patients underwent nutritional assessment prior to surgery. Body mass index (BMI) was calculated from measured height and weight and categorized as obese (\u2265 30 kg\/m<jats:sup>2<\/jats:sup>), overweight (25\u201029.9 kg\/m<jats:sup>2<\/jats:sup>), or normal (18.5\u201024.9 kg\/m<jats:sup>2<\/jats:sup>). Clinical outcomes, including disease\u2010specific survival, recurrence\u2010free survival, and overall survival, were compared by BMI group using Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>From 2000 to 2009, 155 patients (90 men, 65 women) of median age 57 years (range, 18\u201086 years) were included. Baseline characteristics were similar by BMI group. Obesity was significantly associated with adverse disease\u2010specific survival compared with normal weight in univariable (hazard ratio [HR]\u2009=\u20092.65, 95% confidence interval [CI]\u2009=\u20091.07\u20106.59; <jats:italic>P<\/jats:italic>\u2009=\u2009.04) and multivariable analyses (HR\u2009=\u20095.01; 95% CI\u2009=\u20091.69\u201014.81; <jats:italic>P<\/jats:italic>\u2009=\u2009.004). A consistent association was seen between obesity and worse recurrence\u2010free survival (HR\u2009=\u20091.87; 95% CI\u2009=\u20090.90\u20103.88) and between obesity and worse overall survival (HR\u2009=\u20092.03; 95% CI\u2009=\u20090.88\u20104.65) though without reaching statistical significance (<jats:italic>P<\/jats:italic>\u2009=\u2009.09 and <jats:italic>P<\/jats:italic>\u2009=\u2009.10, respectively) in multivariable analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In this retrospective study, obesity was an adverse independent prognostic variable. This association may not have been previously appreciated due to confounding by multiple factors including prediagnosis weight loss. <jats:bold><jats:italic>Cancer<\/jats:italic> 2014;120:983\u2013991<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28532","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T10:32:34Z","timestamp":1390300354000},"page":"983-991","source":"Crossref","is-referenced-by-count":66,"title":["Impact of obesity on the survival of patients with early\u2010stage squamous cell carcinoma of the oral tongue"],"prefix":"10.1002","volume":"120","author":[{"given":"Neil M.","family":"Iyengar","sequence":"first","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kochhar","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York New York"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick G.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc G.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi K.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Public Health Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A.","family":"Ghossein","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Pino","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Fury","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal G.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay O.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford A.","family":"Hudis","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Dannenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198609043151013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp380"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330807"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20490"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065497"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg107"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp380"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21577"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.08.014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601347"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011191809335"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/23.6.1137"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635589609514478"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20461"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990801)86:3<519::AID-CNCR22>3.0.CO;2-S"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10711"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0372"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.1260"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2636"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.2563"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.121"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.8797"},{"key":"e_1_2_7_29_1","unstructured":"LeviJ SegalLM St.LaurentR LangA RayburnJ.F as in Fat: How Obesity Threatens America's Future2012.http:\/\/healthyamericans.org\/assets\/files\/TFAH2012FasInFatFnlRv.pdf. Accessed September 28 2012. Published September 2012."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182299cde"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910073411501"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21584"},{"key":"e_1_2_7_33_1","first-page":"259","article-title":"BMI throughout life, intake of vitamin supplements and oral cancer in Spain","volume":"156","author":"Nieto A","year":"2002","journal-title":"IARC Sci Publ"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.6374"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1387"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1937"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135846"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0381"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0110"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0241"},{"key":"e_1_2_7_41_1","first-page":"20","article-title":"Elevated levels of urinary prostaglandin E metabolite indicate a poor prognosis in ever smoker head and neck squamous cell carcinoma patients","volume":"20","author":"Kekatpure VD","year":"2009","journal-title":"Cancer Prev Res (Phila)"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-12-0431"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.5496"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.28532","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.28532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:15:33Z","timestamp":1760285733000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.28532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,21]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/cncr.28532"],"URL":"https:\/\/doi.org\/10.1002\/cncr.28532","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,21]]}}}