{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:04:28Z","timestamp":1762506268118,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,5,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Large rearrangements in <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> occur in a small percentage (&lt; 1%) of patients tested for hereditary breast (BC) and ovarian cancer. It is unclear what factors predict BRAC<jats:italic>Analysis<\/jats:italic> Large Rearrangement Test (BART) positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Data from 6 centers were included in this analysis. Individuals with negative Comprehensive BRAC<jats:italic>Analysis<\/jats:italic> tested for BART were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>From 1300 individuals, 42 (3.2%) were BART positivity. Factors positively associated with BART positivity were Myriad score, first\u2010degree relatives with BC, infiltrating BC with ductal carcinoma in situ, younger age at BC diagnosis, estrogen receptor\u2013negative BC for both the first and second BC, and Latin American\/Caribbean ethnicity. Presence of unilateral BC was inversely associated with BART positivity. Several analyses were performed on the variables available to find the model that best predicts for BART positivity. The BART predictive model, including first BC, ovarian cancer, primary maternal ancestry being Latin America\/Caribbean, number of first\u2010degree relatives with BC of 1 or more versus 0, and family history of prostate and pancreatic cancer, had good predictive ability with an area under the curve of 0.77.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Several factors are significantly associated with BART positivity. Among them we have found that Latin American\/Caribbean ancestry, Myriad score, first degree relatives with BC, younger age at BC diagnosis, estrogen receptor\u2013negative status of BC, and infiltrating ductal carcinoma with ductal carcinoma in situ features are significantly associated with BART positivity. A BART predictive model may help in a clinical setting. <jats:bold><jats:italic>Cancer<\/jats:italic> 2014;120:1557\u20131564.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28577","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T12:07:02Z","timestamp":1392206822000},"page":"1557-1564","source":"Crossref","is-referenced-by-count":17,"title":["Characteristics of individuals with breast cancer rearrangements in <i>BRCA1<\/i> and <i>BRCA2<\/i>"],"prefix":"10.1002","volume":"120","author":[{"given":"Sarah A.","family":"Jackson","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Robert H Lurie Comprehensive Cancer Center Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Robert H Lurie Comprehensive Cancer Center Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nengjun","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley R.","family":"McCormick","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute, Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carly","family":"Grant","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute, Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taya","family":"Fallen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cancer Genetics Program Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Crawford","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center, Cancer Risk Program University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Loranger","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center, Cancer Risk Program University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Litton","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Arun","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Vande Wydeven","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology Oncology University of Illinois Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Sidani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology Oncology University of Illinois Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merideth","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent","family":"Hoskins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology Oncology University of Illinois Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Nussbaum","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center, Cancer Risk Program University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Esserman","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center, Cancer Risk Program University of California San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy E.","family":"Garber","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute, Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia G.","family":"Kaklamani","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Robert H Lurie Comprehensive Cancer Center Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Northwestern Cancer Genetics Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0529-1"},{"volume-title":"BRACAnalysis\u00ae Large Rearrangement Test 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