{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:24:12Z","timestamp":1791080652274,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T00:00:00Z","timestamp":1393027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chanel Survivorship Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,5,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Survivors of head and neck squamous cell carcinoma (HNSCC) face excess mortality from multiple causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We used the population\u2010based Surveillance, Epidemiology, and End Results (SEER) cancer registry data to evaluate the causes of death in patients with nonmetastatic HNSCC diagnosed between 1992 and 2005 who survived at least 3 years from diagnosis (long\u2010term survivors). We used competing\u2010risks proportional hazards regression to estimate probabilities of death from causes: HNSCC, second primary malignancy (SPM) excluding HNSCC, cardiovascular disease, and other causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We identified 35,958 three\u2010year survivors of HNSCC with a median age at diagnosis of 60 years (range\u2009=\u200918\u2010100 years) and a median follow\u2010up of 7.7 years (range\u2009=\u20093\u201018 years). There were 13,120 deaths during the study period. Death from any cause at 5 and 10 years was 15.4% (95% confidence interval [CI] \u2009=\u200915.0%\u201015.8%) and 41.0% (95% CI\u2009=\u200940.4%\u201041.6%), respectively. There were 3852 HNSCC deaths including both primary and subsequent head and neck tumors. The risk of death from HNSCC was greater in patients with nasopharynx or hypopharynx cancer and in patients with locally advanced disease. SPM was the leading cause of non\u2010HNSCC death, and the most common sites of SPM death were lung (53%), esophagus (10%), and colorectal (5%) cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Many long\u2010term HNSCC survivors die from cancers other than HNSCC and from noncancer causes. Routine follow\u2010up care for HNSCC survivors should expand beyond surveillance for recurrent and new head and neck cancers.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2014;120:1507\u20131513.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2014 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.28588","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T12:53:15Z","timestamp":1393246395000},"page":"1507-1513","source":"Crossref","is-referenced-by-count":187,"title":["Causes of death in long\u2010term survivors of head and neck cancer"],"prefix":"10.1002","volume":"120","author":[{"given":"Shrujal S.","family":"Baxi","sequence":"first","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York New York"},{"name":"Department of Medicine Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata M.","family":"Patil","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York New York"},{"name":"Department of Medicine Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Oeffinger","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena B.","family":"Elkin","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center New York New York"},{"name":"Department of Public Health Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0729"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22963"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23745"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0289"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1728::AID-CNCR29>3.0.CO;2-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.08.638"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-278796"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.7193"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2011.0053"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21369"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22563"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.7301"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.9288"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-1077"},{"key":"e_1_2_7_17_1","volume-title":"AJCC Cancer Staging Manual","author":"Edge SB","year":"2009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000086827.00805.B5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_7_21_1","unstructured":"Centers for Disease Control and Prevention (CDC) National Center for Health Statistics. 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