{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:21:20Z","timestamp":1792167680636,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1NR010162-01A1"],"award-info":[{"award-number":["RO1NR010162-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1CA122292-01"],"award-info":[{"award-number":["RO1CA122292-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1CA124481-01"],"award-info":[{"award-number":["RO1CA124481-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2014,5,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>To the authors' knowledge, only limited data are available regarding the quality of end\u2010of\u2010life care for patients with hematologic malignancies. In this retrospective cohort study, the quality of end\u2010of\u2010life care was compared between patients with hematologic malignancies and those with solid tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>All adult patients who died of advanced cancer between September 1, 2009 and February 28, 2010 while under the care of the study institution were included. The authors collected baseline demographics and end\u2010of\u2010life care indicators, including emergency room visits, hospitalization, intensive care unit admissions, and systemic cancer therapy use within the last 30 days of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of a total of 816 decedents, 113 (14%) had hematologic malignancies. In the last 30 days of life, patients with hematologic malignancies were more likely to have emergency room visits (54% vs 43%; <jats:italic>P<\/jats:italic>\u2009=\u2009.03), hospital admissions (81% vs 47%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001),\u2009\u2265\u20092 hospital admissions (23% vs 10%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001),\u2009&gt;\u200914 days of hospitalization (38% vs 8%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), intensive care unit admissions (39% vs 8%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and death (33% vs 4%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), chemotherapy use (43% vs 14%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and targeted therapy use (34% vs 11%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) compared with patients with solid tumors. Patients with hematologic malignancies were also less likely to have palliative care unit admissions (8% vs 17%; <jats:italic>P<\/jats:italic>\u2009=\u2009.02). The composite score for aggressiveness of care (with 0 indicating the best and 6 indicating the worst) was significantly higher among patients with hematologic malignancies compared with those with solid tumors (median, 2 vs 0; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). On multivariate analysis, hematologic malignancy was found to be a significant factor associated with aggressive end\u2010of\u2010life care (odds ratio, 6.6; 95% confidence interval, 4.1\u201010.7 [<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001]).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The results of the current study indicate that patients with hematologic malignancies received more aggressive care at the end of life. <jats:bold><jats:italic>Cancer<\/jats:italic> 2014;120:1572\u20131578.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28614","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T16:46:42Z","timestamp":1392742002000},"page":"1572-1578","source":"Crossref","is-referenced-by-count":288,"title":["Quality of end\u2010of\u2010life care in patients with hematologic malignancies: A retrospective cohort study"],"prefix":"10.1002","volume":"120","author":[{"given":"David","family":"Hui","sequence":"first","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Didwaniya","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieberta","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, Kosin University Busan South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Chisholm","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Roquemore","sequence":"additional","affiliation":[{"name":"Clinical Operations Informatics, The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bruera","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Rehabilitation Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2007.0184"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.12.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2006.00745.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12294"},{"key":"e_1_2_7_6_1","first-page":"94","article-title":"Bleeding complications in patients with hematologic malignancies","volume":"39","author":"Franchini M","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.07.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24942"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.5705"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.2092"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.5096"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.9897"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0192"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25077"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.136"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.059"},{"key":"e_1_2_7_17_1","unstructured":"National Quality Forum. 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